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Augmenting Cognition
The Human brain is only 100,000 years old. Yet, this newly evolved organ endows us with unique creative capabilities beyond all other living creatures, including the gift to understand itself. As our very survival and success in life depends on utilizing our brain’s power, intense efforts have begun worldwide to understand the brain, reverse-engineer it and even augment its capacity. Towards this end we harness every trick in the book of mathematics, physics, chemistry, pharmacology, biology, psychology, as well as computer science, information sciences, and engineering – giving rise to the birth to the new AugCog Era. The new AugCog research field focuses on the development of scientifi...
The Boy Who Felt Too Much
An International Bestseller, the Story behind Henry Markram’s Breakthrough Theory about Autism, and How a Family’s Unconditional Love Led to a Scientific Paradigm Shift Henry Markram is the Elon Musk of neuroscience, the man behind the billion-dollar Blue Brain Project to build a supercomputer model of the brain. He has set the goal of decoding all disturbances of the mind within a generation. This quest is personal for him. The driving force behind his grand ambition has been his son Kai, who has autism. Raising Kai made Henry Markram question all that he thought he knew about neuroscience, and then inspired his groundbreaking research that would upend the conventional wisdom about auti...
The Boy who Felt Too Much
An international bestseller, the story behind Henry Markram's breakthrough theory about autism, and how a family's unconditional love led to a scientific paradigm shift. Henry Markram is the Elon Musk of neuroscience, the man behind the billion-dollar Blue Brain Project to build a supercomputer model of the brain. He has set the goal of decoding all disturbances of the mind within a generation. This quest is personal for him. The driving force behind his grand ambition has been his son Kai, who suffers from autism. Raising Kai made Henry Markram question all that he thought he knew about neuroscience, and then inspired his groundbreaking research that would upend the conventional wisdom abou...
Spike-timing dependent plasticity
Hebb's postulate provided a crucial framework to understand synaptic alterations underlying learning and memory. Hebb's theory proposed that neurons that fire together, also wire together, which provided the logical framework for the strengthening of synapses. Weakening of synapses was however addressed by "not being strengthened", and it was only later that the active decrease of synaptic strength was introduced through the discovery of long-term depression caused by low frequency stimulation of the presynaptic neuron. In 1994, it was found that the precise relative timing of pre and postynaptic spikes determined not only the magnitude, but also the direction of synaptic alterations when tw...
Topological Data Analysis
This book gathers the proceedings of the 2018 Abel Symposium, which was held in Geiranger, Norway, on June 4-8, 2018. The symposium offered an overview of the emerging field of "Topological Data Analysis". This volume presents papers on various research directions, notably including applications in neuroscience, materials science, cancer biology, and immune response. Providing an essential snapshot of the status quo, it represents a valuable asset for practitioners and those considering entering the field.
The neocortical column
The columnar organization is currently the most widely held hypothesis to explain the cortical processing of information, making its study of potential interest to any researcher interested in the cerebral cortex, both in a healthy and pathological state. Enough data are now available so that the Blue Brain Project can realistically tackle a model of the sensory column in rat. Few will deny however, that a comprehensive framework of the function and structure of columns has remained elusive. One set of persistent problems, as frequently remarked, is nomenclature. "Column" is used freely and promiscuously to refer to multiple, distinguishable entities; for example, cellular or dendritic minic...
Parallel Computing: On the Road to Exascale
As predicted by Gordon E. Moore in 1965, the performance of computer processors increased at an exponential rate. Nevertheless, the increases in computing speeds of single processor machines were eventually curtailed by physical constraints. This led to the development of parallel computing, and whilst progress has been made in this field, the complexities of parallel algorithm design, the deficiencies of the available software development tools and the complexity of scheduling tasks over thousands and even millions of processing nodes represent a major challenge to the construction and use of more powerful parallel systems. This book presents the proceedings of the biennial International Co...
Rationalist Spirituality
Why does the universe exist and what are you supposed to do in it? This question has been addressed by religions since time immemorial, but popular answers often fail to account for obvious aspects of reality. Indeed, if God knows everything, why do we need to learn through pain and suffering? If God is omnipotent, why are we needed to do good? If the universe is fundamentally good, why are wars, crime, and injustice all around us? In modern society, orthodox science takes the rational high-ground and tackles these contradictions by denying the very need for, and the existence of, meaning. Indeed, many of us implicitly accept the notion that rationality somehow contradicts spirituality. That is a modern human tragedy, not only for its insidiousness, but for the fact that it is simply not true. In this book, the author constructs a coherent and logical argument for the meaning of existence, informed by science itself. A framework is laid out wherein all aspects of human existence have a logical, coh
Wiring Principles of Cerebral Cortex
Cerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cognitions and behaviours. When the wiring is damaged through disease or trauma it may reorganize but this may lead to characteristic pathological behaviours. While there have been significant advances in mapping cortical connectivity, the organizing principles and function of this connectivity are not well understood. On the one hand, there appears to...
Aesthetics of Religion
This volume is the first English language presentation of the innovative approaches developed in the aesthetics of religion. The chapters present diverse material and detailed analysis on descriptive, methodological and theoretical concepts that together explore the potential of an aesthetic approach for investigating religion as a sensory and mediated practice. In dialogue with, yet different from, other major movements in the field (material culture, anthropology of the senses, for instance), it is the specific intent of this approach to create a framework for understanding the interplay between sensory, cognitive and socio-cultural aspects of world-construction. The volume demonstrates th...
