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International Kimberlite Conferences (IKCs) are special events that are held across the world once in four to five years. IKC is the confluence platform for academicians, scientists and industrial personnel concerned with diamond exploration and exploitation, petrology, geochemistry, geochronology, geophysics and origin of the primary diamond host rocks and their entrained xenoliths and xenocrysts (including diamond) to get together and deliberate on new advances in research made in the intervening years. Ever since the organization of first IKC in 1973 and its tremendous success, the entire geological world eagerly look forward to subsequent such conferences with great enthusiasm and excite...
Volume 2, dedicated to Barry Hawthorne, presents papers concerned with the genesis of eclogites, the mineralogy of diamond and its inclusions, exploration methods for kimberlite, the geochemistry of the upper mantle and the character of cratons.
Volume 1 of this special issue of Lithos, dedicated to Roger Clement, presents papers describing the geology and emplacement of several of the recently discovered kimberlites in northern Canada in which diamond mines are now operating. Other papers are concerned with the petrography, age of emplacement, geochemistry and petrogenesis of kimberlites from Canada and other worldwide localities.
Given the established nature of geoscientific knowledge of the Kaapvaal craton compared to the Slave craton, and given the exciting new interdisciplinary results coming from the Kaapvaal Project and from Slave craton studies, scientists working on both cratons were brought together in a workshop to compare and contrast the nature of these two cratons. Of the 54 papers presented at the workshop, 24 are included in this volume. There are clearly major similarities and differences between these two Archean cratons. The crust of both was predominantly formed in the Mesoarchean. Both contain crustal sections consisting of terranes of different ages welded together by Archean accretionary events. ...
From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.
This handbook lays out the science behind how animals think, remember, create, calculate, and remember. It provides concise overviews on major areas of study such as animal communication and language, memory and recall, social cognition, social learning and teaching, numerical and quantitative abilities, as well as innovation and problem solving. The chapters also explore more nuanced topics in greater detail, showing how the research was conducted and how it can be used for further study. The authors range from academics working in renowned university departments to those from research institutions and practitioners in zoos. The volume encompasses a wide variety of species, ensuring the breadth of the field is explored.
How do Supreme Court justices decide their cases? Do they follow their policy preferences? Or are they constrained by the law and by other political actors? The Constrained Court combines new theoretical insights and extensive data analysis to show that law and politics together shape the behavior of justices on the Supreme Court. Michael Bailey and Forrest Maltzman show how two types of constraints have influenced the decision making of the modern Court. First, Bailey and Maltzman document that important legal doctrines, such as respect for precedents, have influenced every justice since 1950. The authors find considerable variation in how these doctrines affect each justice, variation due ...
A brilliant new approach to the Constitution and courts of the United States by Supreme Court Justice Stephen Breyer.For Justice Breyer, the Constitution’s primary role is to preserve and encourage what he calls “active liberty”: citizen participation in shaping government and its laws. As this book argues, promoting active liberty requires judicial modesty and deference to Congress; it also means recognizing the changing needs and demands of the populace. Indeed, the Constitution’s lasting brilliance is that its principles may be adapted to cope with unanticipated situations, and Breyer makes a powerful case against treating it as a static guide intended for a world that is dead and gone. Using contemporary examples from federalism to privacy to affirmative action, this is a vital contribution to the ongoing debate over the role and power of our courts.