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Endometriosis is one of the most common gynecological diseases, causing pelvic pain, infertility, and cancer. The condition reduces the quality of life for the estimated 10% of menstruating women who are affected by it. This book provides a clear insight into the pathogenesis and pathophysiology of endometriosis—essential information for clinicians intending to successfully treat the condition. The first part covers a range of topics including stem cells, NK cells, macrophages, inflammation, cytokines, epigenetics, prostaglandin, sex steroids, aromatase, apoptosis, nerve fibers, and malignant transformation to aid in understanding the pathogenesis and pathophysiology of the disease. The second part provides useful tools for therapy, specifically, notable recent techniques in prevention, imaging, biomarkers, medical treatments, surgical treatments, prevention of recurrence, and infertility treatments. Each chapter was written by an expert in the field, with nearly 40 researchers and clinicians contributing to the work. This book will be highly useful to clinicians as well as to research scientists who are interested in this enigmatic disease.
This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades...
Delve into the realm of statistical methodology for mediation analysis with a Bayesian perspective in high dimensional data through this comprehensive guide. Focused on various forms of time-to-event data methodologies, this book helps readers master the application of Bayesian mediation analysis using R. Across ten chapters, this book explores concepts of mediation analysis, survival analysis, accelerated failure time modeling, longitudinal data analysis, and competing risk modeling. Each chapter progressively unravels intricate topics, from the foundations of Bayesian approaches to advanced techniques like variable selection, bivariate survival models, and Dirichlet process priors. With practical examples and step-by-step guidance, this book empowers readers to navigate the intricate landscape of high-dimensional data analysis, fostering a deep understanding of its applications and significance in diverse fields.
Awaken Your Sacred Feminine Self and Reclaim the Fierce, Vibrant Goddess You Are You hold an awesome power within—the power to heal, transform, love, and live the kind of joyful life that grabs hold of the soul and never lets go. That power has been under your nose, literally, this whole time. Rhoda Jordan Shapiro guides you on an inspiring journey toward knowing, loving, and celebrating your body. Magic Within features rituals, affirmations, meditations, journaling, and breathwork that can help you heal and connect to your womb. These practices can bolster every aspect of your life, from money and career to wellness and spiritual fulfillment. Even if you don't have a womb, this book offers ways to align with its energy and manifest your desires. When you connect to your inner power, you can love and express your own unique magic without any constraints or hesitations.
This book provides essential information on the epidemiology, molecular and genetic features, anti-CCR4 antibody therapy and a nationwide study of transplantation on human T-leukemia virus type-I (HTLV-1) and adult T-cell leukemia/lymphoma (ATL). This rare but important disease has restricted endemic areas and distinct clinical features such as a high frequency of hypercalcemia, strong predisposition to infection and poor response to chemotherapy, aspects which set ATL apart from other types of non-Hodgkin lymphoma. Given the small number of patients, enrollment in clinical trials has not been feasible, and establishing treatment standard has been difficult but new evidence, such as results of nationwide studies on transplantation, have shown new insights and potential treatments. Based on recent evidence, the book presents new treatment methods for ATL and infection prevention of HTLV-1, enabling clinicians, researchers and post-docs specializing in hematology and virology to gain a valuable overview of the disease.
Following the success of three previous editions, this new edition of Newborn Surgery continues to provide the most comprehensive information on the surgical management of neonatal disorders. Each chapter is thoroughly revised and updated, and there are eight new chapters on key topics in the specialty, including neonatal care in the delivery room, specific risks for pre-term infants, surgical safety, tissue engineering and stem cell research, and surgical implications of HIV.
Isting of 4049 references to literature consisting mostly of journal articles. Alphabetical arrangement by primary authors. Entries give bibliographical information and abstracts, as well as subject areas and toxonomic categories. Author, subject indexes.
This book reports on research and developments in human–technology interaction. A special emphasis is given to human–computer interaction and its implementation for a wide range of purposes such as health care, aerospace, telecommunication, and education, among others. The human aspects are analyzed in detail. Timely studies on human-centered design, wearable technologies, social and affective computing, augmented, virtual and mixed reality simulation, human rehabilitation, and biomechanics represent the core of the book. Emerging technology applications in business, security, and infrastructure are also critically examined, thus offering a timely, scientifically grounded, but also profe...
Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critic