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Ancient Ryukyu
Who are the people of the Ryukyu Islands? How could they survive and prosper on small, isolated islands? How did the independent Ryukyu Kingdom become a major player in East Asian medieval trade? Ancient Ryukyu explores 30,000 years of human occupation in the Ryukyu Islands, from the earliest human presence in the region up to A.D. 1609 and the emergence of the Ryukyu Kingdom. It focuses on the unique geopolitical position of the islands, their environment, and the many human communities whose historical activities can be discerned. Drawing on the impressive work of dozens of local archaeologists who have brought the islands’ early history to life, Richard Pearson describes explorers and s...
Multidrug Resistance-associated Proteins
Organisms are said to be drug-resistant when drugs meant to neutralise them have reduced effect. When an organism is resistant to more than one drug, it is said to be multi-drug resistant. The most prominent example of this is antibiotic resistance. Drug resistance is also found in some tumour cells, which makes it more difficult to use chemotherapy to attack tumours made of those cells. When a drug such as an antibiotic is administered, those which have a genetic resistance to the drug will survive and reproduce, and the new population will be drug-resistant. This book provides in depth research on multi-drug resistance and its impact on neuorology. This includes studies on GS-X Pump/Multidrug Resistance Proteins, Quantitation of O6 -- Methylguanine, Therapeutic Responses to Chemotherapy, Profiles in Cancer, Neurodegenerative Diseases and Multiple Sclerosis.
Vascular Engineering
This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
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