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The Plasma Proteins
The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume I is a systematic account of the structure, function, and genetic control of plasma proteins. Clinical relevance is introduced in terms of principles, with emphasis on human proteins. Animal proteins are also used as examples in some cases. Comprised of nine chapters, this volume begins with a historical background on plasma proteins, along with their nomenclature, characterization, and genetic markers. The primary structure and three-dimensional conformation of plasma proteins are also considered. The discussion then turns to the chemical, physical, and biological properties of various plasma proteins such...
Electrophoresis
Electrophoresis: Theory, Methods, and Applications, Volume II focuses on the contributions of electrophoresis in the advancement of knowledge on proteins, as well as in the fields of biochemistry, physiology, and medicine. The selection first offers information on the interpretation of electrophoretic mobilities, including theories for other models, electrophoresis of polyelectrolytes, and theory for a rigid spherical particle. The text then takes a look at primary protein structures and nomenclature and identification of the normal human serum proteins. Discussions focus on principles of nomenclature of the serum constituents; methods of identification of an isolated antigen; principal meth...
Contemporary Topics in Molecular Immunology
New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the pro...
Mechanisms of Cell-Mediated Cytotoxicity
The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, September 14-16, 1981. The Workshop brought together for the first time leading investiga tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity. Formal research presentations were held to a minimum, the emphasis being on open discussion of current knowledge about mechanisms of cytoxicity in each of the systems under consideration. The major objectives of the Workshop were 1) to compare and integrate what is known about the mechanism(s) of cytoxicity in each system; 2) to determine whether, on the basis of information in hand, it seems likely that the mechanisms of cytotoxicity in the various systems are the same or are unique; and 3) to stimulate thinking about new approaches to elucidating the fundamental mechanisms by which certain cells are able to kill other cells.
Advances in Immunology
Advances in Immunology
Biological Response Mediators and Modulators
Biological Response Mediators and Modulators explains that the behavior of a cell depends upon the absorption of the ligand, the quantity of functional receptors existing for ligand recognition and binding, and the transduction of the signal through successive intercellular events. The book presents such model systems as the low-density lipoprotein (LDL) receptor, the epidermal growth factor receptor, and the insulin receptor. The LDL receptor is a model for a class of surface receptors that facilitate the cellular application of macromolecules through the process of receptor-mediated endocytosis. The book discusses the general characteristics of receptor-mediated endocytosis. Another topic of interest is the property of growth-related cell surface receptors. The section that follows describes the function of these receptors as tyrosine-specific protein kinases, which is related to the protein yields of some viral oncogenes. The amount of receptors in a cell depends upon the rates of synthesis and inactivation. The book will provide valuable insights for scientists, cytologists, students, and researchers in the field of chemistry.
Complement Regulatory Proteins
From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book ...
Biological Amplification Systems in Immunology
Interest in complement developed at the end of the nineteenth century from observations on cellular and humoral defense mechanisms against bacteria. It was recognized at that time that there were factors in body fluids of animals and man that were capable of killing and lysing bacteria in the absence of cellular factors. Due to the efforts of two of the founders of immunology, Bordet and Ehrlich, and their colleagues, by 1912 the multicomponent nature of complement action was well recognized, the sequence of reaction of the components in the lysis of erythrocytes was defined, complement fixation as a major tool for studying antibody-antigen interaction was well established, and studies on th...
Immunochemistry of Proteins
The structural features responsible for the immunogenicity of certain parts of native protein molecules have been of interest to immunochem ists and protein chemists for over three decades. However, until re cently no concerted effort was (or could be) devoted to the elucidation of the complete antigenic structure of a protein. In order for these en deavors to be successful and meaningful, knowledge of both the amino acid sequence and the detailed three-dimensional structure of the protein is necessary. Such information was not available for a protein until early in the 1960s. This and the fact that protein chemistry was not in fact sufficiently developed early in the 1960s to enable the suc...
