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Molecular Interactions in Bioseparations
Rapid advances in molecular biology have accelerated the production of a great number of protein-based therapeutic agents. The major cost in producing these proteins appears to be associated with their purification from the complex mixture of the crude extract. A major challenge to the protein biochemist and the biochemical engineer is the development of rapid, efficient, and cost-effective purification systems. This volume presents state-of-the-art reviews of current methods used in the purifica tion of biological macromolecules that are based on molecular interactions. Thus, the major emphasis is placed on affinity-related techniques. Part I provides a general introduction to affinity chro...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Immobilized Enzymes For Industrial Reactors
Immobilized Enzymes for Industrial Reactors aims to guide the engineer and scientist along the path toward the industrial application of immobilized enzymes. It is necessary to identify the hazards and pitfalls that will be encountered, not only in the initial research efforts, but also during the final engineering phases of a commercial program. Each contributing factor in an immobilized enzyme system will be scrutinized by the authors in an effort to accomplish the overall objectives. This book comprises 10 chapters, with the first being an introduction to and general history of immobilized enzymes. The next chapters go on to discuss basic enzymology; controlled-pore glasses for enzyme immobilization; carriers; immobilization by adsorption and inorganic bridge formation; immobilization by covalent attachment and by entrapment; characteristics of free vs. immobilized enzymes; immobilized coenzymes; design and operation of immobilized enzyme reactors; and applications of immobilized enzymes. This book will be of interest to practitioners in the fields of chemistry and engineering.
Biochemical Technology, Part A
In December 1992, the Department of Pure and Applied Biochemistry at the Chemical Center in Lund, Sweden, organized an international meeting, the Mosbach Symposium on Biochemical Technology, to celebrate the 60th birthday of professor Klaus Mosbach, one of the founders of modern biotechnology. The history of Pure and Applied Biochemistry had its start in 1970, a couple of years after the foundation of the Chemical Center. Klaus Mosbach has been its professor and head of Pure and Applied Biochemistry since its start. During the 1980's he also maintained a professorship at the ETH in Zürich, Switzerland. Professor Mosbach is internationally well-known and he has world-leading position within ...
Structure and Dynamics of Confined Polymers
Polymers are essential to biology because they can have enough stable degrees of freedom to store the molecular code of heredity and to express the sequences needed to manufacture new molecules. Through these they perform or control virtually every function in life. Although some biopolymers are created and spend their entire career in the relatively large free space inside cells or organelles, many biopolymers must migrate through a narrow passageway to get to their targeted destination. This suggests the questions: How does confining a polymer affect its behavior and function? What does that tell us about the interactions between the monomers that comprise the polymer and the molecules tha...
NASA Tech Brief
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Cytokine Knockouts
Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Neonatal Immunity
A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.
