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Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases
Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sc...
Plant Derived Bioactive Compounds in Human Health and Disease
This book offers a comprehensive review of the multifaceted role of phytochemicals in promoting human health and combating diseases. The initial chapters introduce phytochemicals, navigate the natural health landscape, and provide a foundational understanding of these bioactive compounds. The book unfolds the role of phytochemicals as a formidable defense against oxidative stress and explores the unique health benefits and nutritional significance of phytochemicals found in fruit peels. The subsequent chapters further discuss the therapeutic potential of phytochemicals, detailing their role in combating multidrug-resistant bacterial infections and modulating critical pathways in inflammation...
The New Testosterone Treatment
Written by the leading authority on hormone receptors and prostate cancer, this book reveals the surprising truth about how you can prevent and treat breast cancer, prostate cancer, and Alzheimer's with testosterone and other FDA-approved drugs.For decades, doctors have sought to combat prostate cancer under the mistaken assumption that testosterone fueled its growth. But the latest research into the nature of hormone receptors and therapies using bioidentical instead of synthetic hormones have caused a shift in thinking and new hope for treating this cancer with testosterone. Today the medical profession equates a diagnosis of Alzheimer's with a death sentence. In fact, the only thing docto...
Novel Aspects in Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) has turned from a universally fatal to a highly curable disease in little more than four decades. Even though differences in outcome continue to exist between children and adults, intense efforts are under way to overcome this discrepancy and improve the prognosis of adult patients as well. This exemplary progress in ALL therapy has been possible by the combination of an increasingly better understanding of the biology of the disease, availability of a range of effective drugs, and astute designs and relentless executions of many clinical trials. ALL is a complex disease requiring complex therapy. Whereas this book cannot provide a comprehensive review of e...
Biology and Conservation of Horseshoe Crabs
Horseshoe crabs, those mysterious ancient mariners, lured me into the sea as a child along the beaches of New Jersey. Drawn to their shiny domed shells and spiked tails, I could not resist picking them up, turning them over and watching the wondrous mechanical movement of their glistening legs, articulating with one another as smoothly as the inner working of a clock. What was it like to be a horseshoe crab, I wondered? What did they eat? Did they always move around together? Why were some so large and others much smaller? How old were they, anyway? What must it feel like to live underwater? What else was out there, down there, in the cool, green depths that gave rise to such intriguing creatures? The only way to find out, I reasoned, would be to go into the ocean and see for myself, and so I did, and more than 60 years later, I still do.
Molecular, Cellular, and Tissue Engineering of the Vascular System
This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanis...
Living with Alzheimer's
News of Alzheimer’s disease is constantly in the headlines. Every day we hear heart-wrenching stories of people caring for a loved one who has become a shell of their former self, of projections about rising incidence rates, and of cures that are just around the corner. However, we don't see or hear from the people who actually have the disease. In Living with Alzheimer’s, Renée L. Beard argues that the exclusively negative portrayals of Alzheimer’s are grossly inaccurate. To understand what life with memory loss is really like, Beard draws on intensive observations of nearly 100 seniors undergoing cognitive evaluation, as well as post-diagnosis interviews with individuals experiencin...
