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One of the Sunday Times paperbacks of the Year 2020 One of the Financial Times best books of 2020 'Totally gripping'-- Simon Sebag Montefiore 'Pilecki is perhaps one of the greatest unsung heroes of the second world war ... this insightful book is likely to be the definitive version of this extraordinary life' -- Economist Would you sacrifice yourself to save thousands of others? In the Summer of 1940, after the Nazi occupation of Poland, an underground operative called Witold Pilecki accepted a mission to uncover the fate of thousands of people being interned at a new concentration camp on the border of the Reich. His mission was to report on Nazi crimes and raise a secret army to stage an ...
A self-portrait by one of Australia’s greatest artists, a man mistakenly portrayed as a hermit
At a 1921 garden party, murder is on the menu... The sudden death of her employer sets loyal maid Anna Fairweather on a dangerous quest for justice. Discovering who killed the quarrelsome Colonel will require joining forces with the victim's attractive nephew, Jerome Townson, but is the charming Mr. Townson hiding darker motives than anyone guesses? A formidable dowager, an incompetent Chief Constable, and a host of greedy relations become obstacles in Anna's search for the truth. Will the head butler and the other inscrutable household servants become her allies? Or will Anna face her ultimate fate - and a ruthless killer - alone?
This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the t...
Ion Transport is a collection of papers from the Smith Kline & French Research "Symposium on Ion Transport" held in Cambridge, on April 12-14, 1989. These papers focus on the plasma membrane, particularly on the three main classes of transporters, namely, pumps, exchangers, and channels. Some papers discuss the different experimental approaches from electrophysiological and ion flux measurements through pharmacology, molecular biology, electrostatics, and computer modeling. Other papers discuss the P-type cation pump, a class of ATP-driven ion pumps, which is determined from its subunit composition and from the results of the hydrolysis of ATP. Several papers explain the techniques used in i...
Turbellaria, the mainly free-living flatworms, and some of their parasitic relatives, are among the simplest of the metazoa and, as such, provide ideal models for a wide range of fundamental studies. The 60 contributions to Biology of Turbellaria and some Related Flatworms cover taxonomy and phylogeny, biogeography and genetics, ecology and behaviour, Anatomy and ultrastructure, development and regeneration, genes and sequences, and neurophysiology. Biology of Turbellaria and some Related Flatworms is the most recent compilation in the series published in Hydrobiologia since 1981, covering research on these flatworms assembled by the world's leading authorities on the group. Audience: These papers present the advanced student and serious researcher with up to date information on an important, but often neglected group whose place in the animal kingdom demands greater attention.