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Educational Media and Technology Yearbook
The Educational Media and Technology Yearbook has become a standard reference in many libraries and professional collections. It provides a valuable historical record of current ideas and developments in the field. Part One of this updated volume, “Trends and Issues in Learning, Design, and Technology,” presents an array of chapters that develop some of the current themes listed above, in addition to others. In Part Two, “Leadership Profiles,” authors provide biographical sketches of the careers of instructional technology leaders. Part Three, “Organizations and Associations in North America,” and Part Four, “Graduate Programs,” are, respectively, directories of instructional technology-related organizations and institutions of higher learning offering degrees in related fields. Finally, Part Five, the “Mediagraphy,” presents an annotated listing of selected current publications related to the field.
Cardiometabolic diseases and inflammatory responses
Cardiometabolic diseases are driven by both metabolic disorders (obesity, insulin resistance, non-alcoholic fatty liver diseases, and atherosclerosis) and chronic inflammation (e.g. in diabetes, hypertension and autoimmune diseases), leading to coronary artery disease and heart failure. The perivascular or pericardiac adipose tissue expansion affecting both the systemic and tissue compartment is favored in cardiometabolic disease development. This adipose tissue is a major component of the cardiovascular system that is dysregulated during the consumption of fat-enriched diets. Additionally, fat-enriched diets profoundly impact the response of immune cells in specialized tissues, as well as the activation and differentiation of tissue-resident progenitors. This results in both dysfunction and remodeling that is not limited to tissues, but also to cell activity. The fate of cardiovascular diseases associated with metabolic disorders promotes the imbalance in pro- and anti-inflammatory environments.
Primary and Acquired Resistance in Lung Cancer
Lung cancer is one of the leading causes of cancer-related death worldwide with a prevalence of advanced stage in up to 70% of cases and a five-year survival reached in only 5-10% of cases. Targeted therapies and immunotherapy have greatly improved the management of patients with advanced non-small cell lung cancer (NSCLC), particularly adenocarcinoma, and current diagnostic algorithms are based on the molecular analysis of several biomarkers necessary to tailor therapy. In detail, patients harboring sensitive driver alterations within the oncogenes EGFR, BRAF, ALK, ROS1, RET and NTRK1/2/3 can be treated with approved kinase inhibitors (KIs). In addition, drugs against MET, KRAS G12C and other markers are providing interesting results across different clinical trials. Targeted therapies have greatly improved therapeutic options for NSCLC, but resistance inevitably occurs usually after one year of treatment and some patients, although harboring sensitive alterations, never respond to treatment.
Universal Health Coverage and Global Health in Oncology
Cancer is a global burden and has been acknowledged as a dedicated sustainable development goal (SDG) by the WHO. Worldwide cancer care in all its aspects reaching from prevention and early detection up to palliative care is still characterized by extensive inequalities in accessibility, availability, acceptability, affordability, and quality of care. This results in the insufficient implementation of Universal Health Coverage in many countries and regions. Low and middle-income countries (LMICs) but also underserved regions and population groups in industrial countries achieve intensified focus since several years regarding knowledge exchange and support to overcome these inequalities. Research in global cancer care gained extended attention but still has limitations regarding comparability, methodology, and data quality. Therefore, the Research Topic “Universal Health Coverage and Global Health in Oncology” will focus on research approaches and results of cancer care implementation and its barriers that can be transferred to other countries.
