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Information Retrieval Technology
This book constitutes the refereed proceedings of the 8th Information Retrieval Societies Conference, AIRS 2012, held in Tianjin, China, in December 2012. The 22 full papers and 26 poster presentations included in this volume were carefully reviewed and selected from 77 submissions. They are organized in topical sections named: IR models; evaluation and user studies; NLP for IR; machine learning and data mining; social media; IR applications; multimedia IT and indexing; collaborative and federated search; and the poster session.
Proceedings Of The 19th Annual Meeting Of The Asia Oceania Geosciences Society (Aogs 2022)
The 19th Annual Meeting of the Asia Oceania Geosciences Society (AOGS 2022) was held from 1st to 5th August 2022. This proceedings volume includes selected extended abstracts from a challenging array of presentations at this conference. The AOGS Annual Meeting is a leading venue for professional interaction among researchers and practitioners, covering diverse disciplines of geosciences.
Primary and Acquired Resistance in Lung Cancer
Lung cancer is one of the leading causes of cancer-related death worldwide with a prevalence of advanced stage in up to 70% of cases and a five-year survival reached in only 5-10% of cases. Targeted therapies and immunotherapy have greatly improved the management of patients with advanced non-small cell lung cancer (NSCLC), particularly adenocarcinoma, and current diagnostic algorithms are based on the molecular analysis of several biomarkers necessary to tailor therapy. In detail, patients harboring sensitive driver alterations within the oncogenes EGFR, BRAF, ALK, ROS1, RET and NTRK1/2/3 can be treated with approved kinase inhibitors (KIs). In addition, drugs against MET, KRAS G12C and other markers are providing interesting results across different clinical trials. Targeted therapies have greatly improved therapeutic options for NSCLC, but resistance inevitably occurs usually after one year of treatment and some patients, although harboring sensitive alterations, never respond to treatment.
Cardiometabolic diseases and inflammatory responses
Cardiometabolic diseases are driven by both metabolic disorders (obesity, insulin resistance, non-alcoholic fatty liver diseases, and atherosclerosis) and chronic inflammation (e.g. in diabetes, hypertension and autoimmune diseases), leading to coronary artery disease and heart failure. The perivascular or pericardiac adipose tissue expansion affecting both the systemic and tissue compartment is favored in cardiometabolic disease development. This adipose tissue is a major component of the cardiovascular system that is dysregulated during the consumption of fat-enriched diets. Additionally, fat-enriched diets profoundly impact the response of immune cells in specialized tissues, as well as the activation and differentiation of tissue-resident progenitors. This results in both dysfunction and remodeling that is not limited to tissues, but also to cell activity. The fate of cardiovascular diseases associated with metabolic disorders promotes the imbalance in pro- and anti-inflammatory environments.
