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Deciphering the T Cell Response in SARS-CoV-2 Infection
COVID-19 is a recently emerged infectious disease caused by the novel coronavirus SARS-CoV-2. The immune system has a primary role in pathogen elimination and a rapid and effective response can limit disease severity. In this context, T cells play the major role in cell mediated adaptive immune response. The protective role of CD4+ and CD8+ T cells has been inferred from studies on patients who recovered from SARS and MERS and accumulating data are now showing their relevance in SARS-CoV-2 infection. Moreover, memory T cells induced by previous pathogens can shape the susceptibility to, and the clinical severity of other infections, but the complete picture has yet to be elucidated. If the virus is not rapidly eliminated, COVID-19 may progress towards a secondary inflammatory phase that is directly responsible for a worsening in clinical symptoms and immune system impairment. Besides marked lymphopenia, COVID-19 patients’ T cell compartment displays several alterations involving different subpopulations of T cells in terms of phenotype, metabolic profile and functionality.
A Solution to the Crises of Soil, Water, and Climate in Plant Production
This book contains information on solutions to soil, water and environmental issues. The deterioration of fertile soil, fresh, clean water, and hygienic and green environments for many reasons have created concerns among the scientific community. Soil, water and the environment are threatened by chemical applications (pesticides and fertilizers, for example), natural disasters (erosion, volcanic eruptions, etc.) and other anthropogenic activities (GHG emission, deforestation, urbanization, and more). Life is dependent on these resources. If the soil is lost, from where can we produce food? If water is lost, how will life persist? If the environment is not clean, how will living beings (humans, animals and birds) survive? This book demonstrates critical thinking about how we might save these precious resources.
Plant Derived Bioactive Compounds in Human Health and Disease
This book offers a comprehensive review of the multifaceted role of phytochemicals in promoting human health and combating diseases. The initial chapters introduce phytochemicals, navigate the natural health landscape, and provide a foundational understanding of these bioactive compounds. The book unfolds the role of phytochemicals as a formidable defense against oxidative stress and explores the unique health benefits and nutritional significance of phytochemicals found in fruit peels. The subsequent chapters further discuss the therapeutic potential of phytochemicals, detailing their role in combating multidrug-resistant bacterial infections and modulating critical pathways in inflammation...
