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¨The atherosclerotic process is considered to be driven by an imbalance between proand anti-inflammatory actions. Still, the inflammatory state in patients with coronary artery disease (CAD) remains to be clarified. Annexin A1 (AnxA1) is a glucocorticoidinduced protein which may have a key role in the anti-inflammatory response as a mediator of glucocorticoid effects. The general aim of this thesis was to deepen the knowledge of pro- and antiinflammatory mechanisms in CAD via phenotypic assessments of immune cell subsets, in particular CD56+ T cells, and exploration of AnxA1. The long-term goal is to reveal basic mechanisms that will lead to the development of biomarkers, which may be used ...
Inflammation is closely associated with development of atherosclerosis. The proteolytic enzyme matrix metalloproteinase (MMP)-9 is considered to play a prominent role in this process. MMP-9 has also been introduced as a marker for plaque vulnerability. Still, the possible mechanisms behind altered levels of MMP-9 and its tissue inhibitors (TIMPs) in patients with atherosclerotic disease remain unclear. The general aim of this thesis was to compare leukocyte-derived MMP-9 and TIMPs in patients with coronary artery disease (CAD) and healthy controls and to further relate the findings to psychological stress and glucocorticoid sensitivity. Levels of leukocyte-derived MMP-9 and TIMP-1 showed a s...
The atherosclerotic process and its consequences are considered driven by an imbalance between pro- and ant-inflammatory actions. One contributing factor in this scenario is an altered regulation of apoptosis, which affects both immune, vascular and myocardial cells. The general aim of this thesis was to measure soluble markers of apoptosis in peripheral venous blood, in various clinical stages of coronary artery disease (CAD) and to further identify possible sources with specific focus on natural killer (NK) cell apoptosis and myocardial ischemia-reperfusion (IR)-injury. There was evidence of an increased apoptosis of NK cells, but not T cells, in the circulation of CAD patients. Spontaneou...
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Denna bok är anpassad till dig som ska eller har börjat konditionsträna din hund och vill veta mer om konditionsträning. Den innehåller träningslära med konkreta träningstips, träningsmallar och träningsupplägg för friska hundar. För många har konditionsträning blivit en livsstil och för annan har det medfört en total ändring av livsbetingelserna till det positiva. För hunden och hundägaren finns stora hälsovinster att göra såväl för kroppens välmående som för de mentala processerna. Förarens motivation och fantasi avgör valet av träningsmetod. Behovet och utformningen av konditionsträningen är väldigt individuell beroende på vad hunden ska användas till o...
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