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Brucella is a genus of Gram-negative, facultative, intracellular bacteria that are highly pathogenic for a variety of mammals, including humans. Recently, the World Health Organization cited brucellosis to be the world's most widespread zoonosis. An important feature of the pathogenicity of these organisms is their ability to survive and replicate within the host macrophages. However, the mechanism for this is unclear. In addition, none of the classical bacterial virulence factors found in other bacterial pathogens have been found in the genomes of the 40 Brucella species and biovars analyzed to date. Nevertheless, the application of systems biology approaches in recent years has transformed...
The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.
¿Cómo abordar la crisis del coronavirus? ¿Cómo hay que comunicarla y, sobre todo, afrontarla política y socialmente? Le pedimos a la ciencia que nos aporte certezas, una respuesta inmediata, que encuentre la vacuna en tiempo récord, mientras que durante años apenas se ha invertido en investigación. Ignacio López-Goñi analiza las razones de la crisis de la COVID-19 y nos da algunas claves para el futuro, porque esta no será la única pandemia que vamos a vivir. «Esta pandemia ha puesto de manifiesto cómo funciona la ciencia.» Ignacio López-Goñi
"Writing in a clear and comprehensive writing style, [the authors] show how the U.S. political, social, and economic environments make disinformation believable to large numbers of people and difficult to stop or prevent." - Library Journal, Starred Review "Everyone, whether they work in the public sector or are private citizens, will find this book invaluable.” - Booklist, Starred Review Disinformation made possible by rapid advances in cheap, digital technology, and promoted by organized networks, thrives in the toxic political environment that exists within the United States and around the world. In Lies that Kill, two noted experts take readers inside the world of disinformation campai...
From the remarkable minds of Sputnik Futures, this visually engaging exploration of the microbes that surround us and how these unseen powerhouses are shaping our future is perfect for readers of I Contain Multitudes and 10% Human. Let’s face it, microbes rule the world! Bacteria, fungi, archaea, protozoa, algae, even viruses—these microorganisms may go unseen, but the impact they have on our lives is unmistakable. From panspermia (the bacteria dust from our galaxy) and the microbiomes of our homes and our environments, to emerging research on microbes’ role in our social emotions of love and empathy, and the realization that we are a superorganism, made up of trillions of bacteria tha...