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Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.
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Even as a teenager, Joseph Albert Calamia understood the need to live by the rule of law. In high school, a class bullys continual harassment of a skinny Hispanic kid led Joseph to confront him. But he wisely did so with the coachs permission, challenging the boy to a boxing match. The tormentor went down quickly and Calamia settled the score under the jurisdiction of the high school coach. Calamia began his career as a criminal defense attorney in El Paso, Texas, in 1949. He was a crusader for justice, considered by many to be akin to Don Quixote, tilting at windmills. But he disagreed, "The big difference is that my demons were real." His demons were the institutionalized practices that fa...
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
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