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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Where Is Abbas Kiarostami?
"When Abbas Kiarostami suddenly passed away in July 2016, he was already an iconic figure in world cinema-and his reputation as a master filmmaker has only grown since. In this book, celebrated scholar Hamid Dabashi offers a new way of looking at Kiarostami's art world, one that questions the very idea of film philosophy. Dabashi's authoritative account of the philosophical resonances of Kiarostami's oeuvre offers an iconoclastic critique of the field's Eurocentrism and, in vivid prose, makes the case for a new method of appreciating the work of this essential figure. The result is a provocative perspective on the totality of Kiarostami's legacy that, with deep roots in Iranian aesthetic and Persian poetic and philosophical traditions, overcomes film's provincial preoccupation with its Western heritage and charts a new path forward for film philosophy."--
Encyclopedia of Obesity
Obesity is a serious health issue and is a key discussion and research point in several disciplines from the social sciences to the health sciences and even in physical education. This text is a much-needed authoritative reference source covering major issues of, and relating to, obesity.
The Rinehart Frames
The Rinehart Frames questions the boundaries of diaspora and narrative through a tethering of voices and forms that infringe upon monolithic categorizations of Blackness and what can be intersected with it.
Handbook of Research on Data Science for Effective Healthcare Practice and Administration
Data science has always been an effective way of extracting knowledge and insights from information in various forms. One industry that can utilize the benefits from the advances in data science is the healthcare field. The Handbook of Research on Data Science for Effective Healthcare Practice and Administration is a critical reference source that overviews the state of data analysis as it relates to current practices in the health sciences field. Covering innovative topics such as linear programming, simulation modeling, network theory, and predictive analytics, this publication is recommended for all healthcare professionals, graduate students, engineers, and researchers that are seeking to expand their knowledge of efficient techniques for information analysis in the healthcare professions.
How Fuzzy Concepts Contribute to Machine Learning
This book introduces some contemporary approaches on the application of fuzzy and hesitant fuzzy sets in machine learning tasks such as classification, clustering and dimension reduction. Many situations arise in machine learning algorithms in which applying methods for uncertainty modeling and multi-criteria decision making can lead to a better understanding of algorithms behavior as well as achieving good performances. Specifically, the present book is a collection of novel viewpoints on how fuzzy and hesitant fuzzy concepts can be applied to data uncertainty modeling as well as being used to solve multi-criteria decision making challenges raised in machine learning problems. Using the multi-criteria decision making framework, the book shows how different algorithms, rather than human experts, are employed to determine membership degrees. The book is expected to bring closer the communities of pure mathematicians of fuzzy sets and data scientists.
AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Guidebook for Systems Applications in Astrobiology
This book addresses the timely subject of systems applications in astrobiology. It demonstrates how astrobiology – a multidisciplinary, interdisciplinary, and transdisciplinary field of science – can benefit from adopting the systems approach. Astrobiology draws upon its founding sciences, such as astronomy, physics, chemistry, biochemistry, geology, and planetary sciences. However, astrobiologists can encounter difficulties working across these fields. The systems approach, we believe, is the best contemporary approach to consider astrobiology holistically. The approach is currently used in other fields, such as engineering, which uses systems analysis routinely. Such an approach needs ...
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
