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The Annotated Hodgkin and Huxley
The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley’s rigorous scientific thought, elegant experimenta...
The Annotated Hodgkin and Huxley
Historical background -- Paper 1 -- Paper 2 -- Paper 3 -- Paper 4 -- Paper 5.
The olivo-cerebellar system
During the last decades, investigations on the olivo-cerebellar system have attained a high level of sophistication, which led to redefinitions of several structural and functional properties of neurons, synapses, connections and circuits. Research has expanded and deepened in so many directions and so many theories and models have been proposed that an ensemble review of the matter is now needed. Yet, hot topics remain open and scientific discussion is very lively at several fronts. One major question, here as well as in other major brain circuits, is how single neurons and synaptic properties emerge at the network level and contribute to behavioural regulation via neuronal plasticity. Othe...
Think Tank
Essays that explore quirky, counterintuitive aspects of brain function and “make us realize that what goes on in our minds is nothing short of magical” (Scientific American). Neuroscientist David J. Linden approached leading brain researchers and asked each the same question: “What idea about brain function would you most like to explain to the world?” Their responses make up this one-of-a-kind collection of popular science essays that seeks to expand our knowledge of the human mind and its possibilities. The contributors, whose areas of expertise include human behavior, molecular genetics, evolutionary biology, and comparative anatomy, address a host of fascinating topics ranging fr...
Sodium Channels and Neuronal Hyperexcitability
Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types. This book explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration. The authors present the most current research on sodium channels and neuronal function. Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy. Includes coverage of channelopathies, sodium channel gene expression, the modulation of sodium channels, and molecular mechanisms of gating and drug block of sodium channels.
Science
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Molecular and Functional Diversity of Ion Channels and Receptors
This volume brings together an interdisciplinary group of scientists working with different neurotransmitter receptors and ion channels to discuss how the large amount of information obtained from molecular cloning can be used to advance knowledge of cell and tissue function. It documents the physiological roles of ion channels and receptors, including the functional analysis of subunit composition, role of associated proteins, functional alalysis of native and expressed channels, and physiological and pharmacological investigations of animal models in which specific channels are eliminated or altered.
Developing a 21st Century Neuroscience Workforce
From its very beginning, neuroscience has been fundamentally interdisciplinary. As a result of rapid technological advances and the advent of large collaborative projects, however, neuroscience is expanding well beyond traditional subdisciplines and intellectual boundaries to rely on expertise from many other fields, such as engineering, computer science, and applied mathematics. This raises important questions about to how to develop and train the next generation of neuroscientists to ensure innovation in research and technology in the neurosciences. In addition, the advent of new types of data and the growing importance of large datasets raise additional questions about how to train studen...
