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Statistical Analysis of Next Generation Sequencing Data
Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this grow...
The Casket of Time
“A rose can rest in the casket for a thousand years without fading. An egg can remain there for centuries without going bad. A person could lie there for a hundred years, a thousand years, ten thousand years, completely protected from time." What happens when the world starts to fall apart, and no one will take responsibility for mending it? Sigrun’s family, along with everyone else, finds refuge from the crisis in a new technology called TimeBox®, which lets you hibernate until the world’s problems solve themselves. But Sigrun’s TimeBox® opens early, and she wakes to a city in chaos, overrun by nature. Sigrun joins a roving band of kids and a wise researcher named Grace, who tells...
Analysis and Logic
This volume comprises articles from four outstanding researchers who work at the cusp of analysis and logic. The emphasis is on active research topics; many results are presented that have not been published before and open problems are formulated. Considerable effort has been made by the authors to integrate their articles and make them accessible to mathematicians new to the area.
Place of the Heart
Single mother Harpa loads her reprobate daughter and their belongings into a pickup truck, setting out on a road trip to Iceland's bucolic eastern fjords.
The Mathematics of the Heavens and the Earth
The Mathematics of the Heavens and the Earth is the first major history in English of the origins and early development of trigonometry. Glen Van Brummelen identifies the earliest known trigonometric precursors in ancient Egypt, Babylon, and Greece, and he examines the revolutionary discoveries of Hipparchus, the Greek astronomer believed to have been the first to make systematic use of trigonometry in the second century BC while studying the motions of the stars. The book traces trigonometry's development into a full-fledged mathematical discipline in India and Islam; explores its applications to such areas as geography and seafaring navigation in the European Middle Ages and Renaissance; a...
Moonstone: The Boy Who Never Was
WINNER OF THE SWEDISH ACADEMY'S NORDIC PRIZE 2023 Winner of the Icelandic Literary Prize 'An extraordinary and original writer' A.S. Byatt on Sjón Reykjavik, 1918. The eruptions of the Katla volcano darken the sky night and day. Yet despite the natural disaster, the shortage of coal and the Great War still raging in the outside world, life in the small capital goes on as always. Sixteen-year-old Máni Steinn lives for the movies. Awake, he lives on the fringes of society. Asleep, he dreams in pictures, the threads of his own life weaving through the tapestry of the films he loves. When the Spanish flu epidemic comes ashore, killing hundreds of townspeople and forcing thousands to their sick beds, the shadows that linger at the edges of existence grow darker and Máni is forced to re-evaluate both the society around him and his role in it. Evoking the moment when Iceland's saga culture met the new narrative form of the cinema and when the isolated island became swept up in global events, this is the story of a misfit transformed by his experiences in a world where life and death, reality and imagination, secrets and revelations jostle for dominance.
Dynamical Systems III
This work describes the fundamental principles, problems, and methods of elassical mechanics focussing on its mathematical aspects. The authors have striven to give an exposition stressing the working apparatus of elassical mechanics, rather than its physical foundations or applications. This appara tus is basically contained in Chapters 1, 3,4 and 5. Chapter 1 is devoted to the fundamental mathematical models which are usually employed to describe the motion of real mechanical systems. Special consideration is given to the study of motion under constraints, and also to problems concerned with the realization of constraints in dynamics. Chapter 3 is concerned with the symmetry groups of mech...
