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The Merkel Cell
Since their first description in 1875, Merkel cells have remained an elusive cell type. Their origin as well as their classification as mechanoreceptors have been a matter of controversy and intense discussion. The peptidergic granules in these cells are suggestive of neuroendocrine functions, but their discovery has raised additional questions regarding Merkel cell function. Essential aspects of structure, development and function of normal Merkel cells and Merkel cell carcinoma are presented in short chapters, providing concise and up-to date information on this fascinating cell type.
Molecular Diagnostics in Dermatology and Dermatopathology
Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological diseases. Topics include the integration of newer diagnostic and prognostic techniques with ‘traditional’ histologic approaches, and discussions of regulatory, ethical, legal, economic issues and ‘newer’ technologies. This important diagnostic tool outlines the clinically relevant uses (i.e.; diagnostic, staging and/or prognostic) applications of these techniques in the field of dermatology. Molecular studies that investigate the pathogenesis of skin diseases will be excluded, unless they also have a direct diagnostic utility. The book will be of interest to practicing pathologists, dermatology and pathology residents, dermatologists, and dermatopathologists.
To a Brighter Future
To A Brighter Future is the story of one family's dream and prayer to make a better life for their children. It tells of the growing-up years in a relatively affluent Germany, which quickly changed during the great inflation of the early twenties, then fell into ruin after World War ll This book chronicles the immigration of two young people to Canada in 1928 and follows their struggles to create a "brighter future" for their children in a new homeland. For the young man who came first, there was job searching, jumping the freights, and finding the right piece of land. Together, they experienced the trials and adventures of homesteading in the Peace River Country of northern Alberta. There a...
Cancer Signaling
Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biolo...
Wound Healing
During the past decade, significant progress in molecular and cellular te- niques has greatly advanced our understanding of the wound healing p- cess. Many of these new techniques have been utilized in the context of more classic models of wound healing. The combination of new and classic approaches has allowed scientists to make exciting discoveries in the field of tissue repair, resulting in an explosion of information about the healing p- cess. Importantly, these new findings have great relevance beyond wound healing itself. The injury repair process cuts across many disciplines, exte- ing to such broad fields as cancer, inflammation, and atherosclerosis. The relevance of the field to the...
Skin Barrier
A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatiti
Merkel Cells, Merkel Cell Carcinoma and Neurobiology of the Skin
Hardbound. The ICS series is proud to publish the proceedings of the 1st Symposium of the Japanese Society for Ultrastructural Cutaneous Biology, which will make a significant contribution to advances in the dermatological field.Dr. Friedrich Merkel first identified the Merkel cells, which he called Tastzellen (touch cells) in 1875. However, it was not until the 1960s that the existence of Merkel cells in the human skin was confirmed by Dr. Cauna using electron microscopy.1902 saw the discovery of the Haarscheiben (hair discs) by Dr. Felix Pinkus who reported that they are many Merkel cells beneath the epidermis of the disc. Today, the Merkel cell-neurite complex in the hair disc is regarded as a slow-adapting type I mechanoreceptor unit.Since 1978, when Drs. Tang and Toker reported the concept of Merkel cell carcinoma, many cases have been identified worldwide. Neurobiology, neuropeptides and interaction between cutaneous innervation and the
Pathologie
Dieser Band des Gesamtwerks „Pathologie" behandelt die Pathologie der Kopf- und Halsregion, der Weichgewebstumoren sowie der Haut. Der erste Teil umfasst alle Erkrankungen, die sich in den Organen der Kopf- und Halsregion beobachten lassen. Alle neuen Tumoren des Weichgewebes, die in den letzten Jahren bekannt wurden, werden im zweiten Teil erfasst. Der dritte Teil beschreibt die entzündlichen und nichtentzündlichen Hauterkrankungen. Geschrieben von führenden Experten dient der Band als Grundlage für die tägliche diagnostische Arbeit.
