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The 2012 International Symposium on Management Intelligent Systems is believed to be the first international forum to present and discuss original, rigorous and significant contributions on Artificial Intelligence-based (AI) solutions—with a strong, practical logic and, preferably, with empirical applications—developed to aid the management of organizations in multiple areas, activities, processes and problem-solving; i.e., what we propose to be named as Management Intelligent Systems (MiS). The three-day event aimed to bring together researchers interested in this promising interdisciplinary field who came from areas as varied as management, marketing, and business in general, computer ...
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
Life on earth arose through the creative interplay of prebiotic conditions on earth and the everlasting reliable macrocosmic changes of light and darkness. The first life molecules were confronted with the Earth's two-faced environment manifesting itself as a rhythm of a damaging light phase (day) and a harmless low light dark phase (night) produced by the apparent celestial movements within the earth-moon-sun system. It required two mutually complementing molecule types: ribonucleic acids and peptides, which had to adapt jointly to that fundamental duality in order to achieve a 'duration across change'. Both combined into a helically intertwined ribonucleopeptide filament as the initial mol...
This book presents a unique overview of urban policy conducted by national authorities in the fifteen 'old' member states of the EU. Focussing on recent changes in the development of the larger cities and changes in policymaking by national authorities with respect to urban development, the book is structured around 15 'country chapters', written by national experts in the field of urban development. The book provides an up-to-date source of information, and will be of importance to anyone involved in the role and development of European cities as well as the formulation and delivery of associated national policies.
Reichel's formative text is designed as a practical guide for health specialists confronted with the unique problems of geriatric patients.
This book addresses the hot topic in audiovisual translation (AVT) of video game localization through the unique perspective of dubbing, an area which has so far received relatively little scholarly focus. The author analyses the main characteristics of video game localization within the context of English-Spanish dubbing, and emphasizes the implications for research and localization as a professional practice. The book will appeal to translation studies scholars and students, as well as AVT professionals looking to understand localization processes from a systematized approach.
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
Ces Actes du Colloque XV pour l'etude du dessin sous-jacent et de la technologie dans la peinture (Bruges, 11-13 septembre 2003), reunissent trente-six etudes traitant d'oeuvres d'art flamand, espagnol, portugais, italien et francais. Ces etudes sont suivies, comme dans les Actes precedents, d'une bibliographie de l'infrarouge.Depuis de nombreuses annees on sait que la peinture ancienne est constituee - outre d'oeuvres dites "originales" - de copies, de repliques et de pastiches, produites dans des ateliers actifs qui faisaient appel a des collaborations. Les bases sur lesquelles on avait fonde jadis les catalogues des maitres sont ebranlees. De nombreuses attributions doivent etre revues. L...