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Membrane Proteins Production for Structural Analysis
This book updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This field has made significant advances since the elucidation of the first 3-D structure of a recombinant G Protein Coupled Receptor (GPCR), rhodopsin, with the structure of several more GPCRs having been solved in the past five years. In fact, the 2012 Nobel Prize in Chemistry was awarded for groundbreaking discoveries on the inner workings of GPCRs. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.
Heterologous Expression of Membrane Proteins
This detailed volume explores protocols for the production of membrane proteins in a panel of heterologous organisms for structural studies. Beginning with techniques using E. coli as a host for the overproduction and purification of membrane proteins, the book continues with chapters covering mammalian membrane protein production in yeast, insect cells, mammalian cells, as well as using virus like particles and acellular systems. Additionally, new detergents and alternatives to detergents allowing membrane protein purification for structural analyses are described. The book closes with a chapter exploring the use of microscale thermophoresis (MST) to evaluate the binding activity of heterol...
The Smoothened Receptor in Cancer and Regenerative Medicine
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging...
From Fundamental Genomics to Systems Biology
Accompanying CD-ROM contains text.
Elaboration de systèmes modèles pour l'étude des relations structure-fonction d'un cytochrome multihémique et de ses partenaires d'oxydo-réduction
LA PRESENCE DE QUATRE HEMES DANS UN CYTOCHROME DE BAS POTENTIEL D'OXIDO-REDUCTION POSE LE PROBLEME DU ROLE DE CHACUN DES HEMES DANS LE MECANISME DE TRANSFERT INTER- ET INTRA-MOLECULAIRE D'ELECTRONS. NOUS AVONS CHOISI D'ABORDER CE SUJET D'UNE FACON ORIGINALE, A L'INTERFACE ENTRE LA CHIMIE ET LA BIOLOGIE, GRACE A L'UTILISATION DE MODELES QUI PERMETTENT D'ELIMINER CERTAINS FACTEURS ET RENDENT LE SYSTEME MOINS COMPLEXE. L'ETUDE DE L'INTERACTION ENTRE LE CYTOCHROME C3 ET UN POLYANION MIMANT LES PARTENAIRES REDOX DE FAIBLE POIDS MOLECULAIRE DU CYTOCHROME A MIS EN EVIDENCE QUE CE PROCESSUS DE COMPLEXATION ETAIT CONTROLE PAR DES EFFETS DE CHARGES ET DE TOPOLOGIE DES PARTENAIRES ET IMPLIQUAIT UN SEUL...
Bacterial Transport
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Membrane Protein Structure and Function Characterization
In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane. Since every membrane protein behaves mostly in a unique way /fashion, knowledge of guidelines and tricks may help to increase chances to express, purify and characterize a peculiar membrane protein. Production of correctly folded protein remains a challenge. Moreover, getting a functional and stable protein requires to optimize membrane mimicking environments that can be detergent or artificial membranes. In some cases, the finding of the correct ligand which will stabilize the desired conformation is needed. In othe...
Membrane Protein Crystallization
This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization. This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.
Membrane Proteins in Aqueous Solutions
This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing det...
