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Climate Engineering
Climate Engineering: A Normative Perspective takes as its subject a prospective policy response to the urgent problem of climate change, one previously considered taboo. Climate engineering, the “deliberate, large-scale manipulation of the planetary environment in order to counteract anthropogenic climate change,” encapsulates a wide array of technological proposals. Daniel Edward Callies here focuses on one proposal currently being researched—stratospheric aerosol injection—which would spray aerosol particles into the upper atmosphere to thus reflect a small portion of incoming sunlight and slightly cool the globe. This book asks important questions that should guide moral and polit...
Steroid Receptor Methods
A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.
Cumulative Subject Index
Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. For easy reference, this volume provides a cumulative subject index covering Volumes 25-44.
Across the Boundaries
Steel argues that previous accounts of extrapolation are inadequate and proposes a better approach that is able to answer methodological critiques of extrapolation from animal models to humans. His work develops the thought that knowledge of mechanisms linking cause to effect can serve as a basis for extrapolation.
Future Aspects in Human In Vitro Fertilization
While the organization of an international congress on in vitro fertilization (IVF) was an entirely new venture for us in 1983, since we had no experience but were full of optimism, we approached the organization of a second Congress in Vien na in 1986 much more calmly. Our experience had increased as had the readiness of many of our friends to help and of people interested in cooperating. However, would our Congress not lose its originality on account of the increased routine? This was certainly a possible danger which we wanted to prevent by means of two counter measures. The first concerned the scientific program: the new and trend-setting aspects of IVF would be discussed primarily rathe...
Comparative Genomics
Comparative genomics: an introduction: sequencing projects and model organisms (M. S. Clark). Drosophila melanogaster: a genetic tool (U. Schafer, H. Jackle). Tunicates: models for chordate evolution and development at low genomic complexity (W. R. Jeffrey). Fugu rubripes: a fish model genome (M. S. Clark, G. Elgar). The mouse and the genomic era (T. J. Wilson, F. Lazner, I. Kola, P. J. Hertzog). Quantitative Trait Loci in domestic animals - complex inheritance patterns (E. Lipkin, m. Soller). Comparative genomics of vertebrates and the evolution of sex chromosomes (J. A. M. Graves, S. Shetty). Insights into mammalian genome organization evolution by molecular cytogenetics (J. Wienberg, L. Froniecke, R. Stanyon). Index.
Catecholamines: Bridging Basic Science with Clinical Medicine
This volume in Advances in Pharmacology focuses on all aspects of catecholamine research, from very basic to medical. It is broad based and covers many areas within physiology and medicine.
HIV: Molecular Biology and Pathogenesis: Viral Mechanisms
The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, ...
Transcription Factor Protocols
The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA...
Embryo Experimentation
New developments in reproductive technology have made headlines since the birth of the world's first in vitro fertilization baby in 1978. But is embryo experimentation ethically acceptable? What is the moral status of the early human embryo? And how should a democratic society deal with so controversial an issue, where conflicting views are based on differing religious and philosophical positions? These controversial questions are the subject of this book, which, as a current compendium of ideas and arguments on the subject, makes an original contribution of major importance to this debate. Peter Singer is the author of many books, including Practical Ethics (CUP, 1979), Marx (Hill & Wang, 1980), and Should the Baby Live? (co-authored with Helga Kuhse, Oxford U.P., 1986).
