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Sialobiology: Structure, Biosynthesis and Function. Sialic Acid Glycoconjugates in Health and Disease
This ebook presents a summary of central aspects of sialobiology (i.e., the study of sialic acid and its relevance to biology). The importance of substitution by the sugar sialic acid and the role played by sialylated structures (eg. glycoproteins, glycolipids, glycoconjugates) in immune recognition, neural cell growth, embryogenesis and disease development including microbial pathogenesis and cancer progression, has become well-established. Since 1995, the field of sialobiology has expanded greatly as many of the key enzymes involved in sialic acid biosynthesis, as well as the vast majority of sialic acid binding lectins involved in immune recognition, have only been cloned, characterised and structural eluciated after the publication of earlier works on the subject. This e-book also covers these recent developments. Chapters in this e-book have been contributed by eminent sialobiologists. Therefore, a book of this nature is timely and will prove to be a definitive volume with a high impact in this field for glycobiologists and cell biologists.
Inborn errors of Carbohydrate Metabolism
Inborn errors of carbohydrate metabolism are a heterogeneous subgroup of inborn errors that are caused by mutations in human genes coding for proteins involved in carbohydrate catabolic and anabolic pathways. Through the breakdown of sugars, carbohydrate catabolism allows a constant supply of energy (e.g. glycolysis), but also involves the breakdown of the cell’s complex oligosaccharides (e.g. lysosomal degradation of surface glycoconjugates) allowing the recycling of monosaccharides. On the other hand, anabolism of carbohydrates (e.g. gluconeogenesis) is required to supply newly synthesized sugars to catabolic pathways, also allowing interconversion of sugars and sustaining the synthetic pathways of complex carbohydrate structures such as glycosaminoglycans and glycans that are the carbohydrate moiety of glycoconjugates involved in multiple biological functions.
Advances in Chromatography
For six decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known make the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. Presents an in-depth review of chaotropic chromatography. Reviews recent advances in HPLC and SFC columns packed with hybrid organic/inorganic particles. Explores new advances in nano-liquid chromatography for proteomics analysis. Outlines the heterogeneity of gangliosides and advances in the chromatographic techniques used in their separation.
Dementia and Neurodegenerative Diseases – Case Report Collection 2022
This Research Topic aims to collect all the Case Reports submitted to the Dementia and Neurodegenerative Diseases section. All the Case Reports submitted to this collection will be personally assessed by the Specialty Chief Editor before the beginning of the peer-review process. Please make sure your article adheres to the following guidelines before submitting it. Case Reports highlight unique cases of patients that present with an unexpected diagnosis, treatment outcome, or clinical course. Only Case Reports that are original and significantly advance the field will be considered: - RARE case with TYPICAL features - FREQUENT case with ATYPICAL features - Cases with a convincing response to new treatments, i.e. single case of off-label use
Devil's Day
"A gripping and unsettling new novel by the award-winning author of The Loney that asks how much we owe to tradition, and how far we will go to preserve it"--
Exciting Times
"This debut novel about an Irish expat millennial teaching English and finding romance in Hong Kong is half Sally Rooney love triangle, half glitzy Crazy Rich Asians high living--and guaranteed to please." --Vogue A RECOMMENDED BOOK FROM: The New York Times Book Review * Vogue * TIME * Marie Claire * Elle * O, the Oprah Magazine * Esquire * Harper's Bazaar * Bustle * PopSugar * Refinery 29 * LitHub * Debutiful An intimate, bracingly intelligent debut novel about a millennial Irish expat who becomes entangled in a love triangle with a male banker and a female lawyer Ava, newly arrived in Hong Kong from Dublin, spends her days teaching English to rich children. Julian is a banker. A banker who...
Come Rain or Come Shine
Faber Stories, a landmark series of individual volumes, presents masters of the short story form at work in a range of genres and styles. When Ray turns up to visit his old university friends Charlie and Emily, he's given a special task: to be so much his useless self that he makes Charlie look good by comparison.But Ray has his own buried feelings to contend with. Decades earlier, he and Emily would listen to jazz when they were alone, and now, as Sarah Vaughan sings through the speakers, he struggles to control everything the sound brings with it.In Kazuo Ishiguro's hands, a snapshot of domestic realism becomes a miniature masterpiece of memory and forgetting.
