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Bioinorganic Chemistry
Bioinorganic chemical knowledge grows more interesting and morecomplex with each passing year. As more details about the usage andutility of metals in biological species and more mechanistic andstructural information about bioinorganic molecules becomesavailable, scientists and students continue to turn their attentionto this blossoming discipline. Rosette Roat-Malone's BioinorganicChemistry: A Short Course provides an accessible survey ofbioinorganic chemistry for advanced undergraduate and graduatestudents. Comprehensive coverage of several topics offers insightinto the increasingly diverse bioinorganic area. Roat-Malone's textconcentrates on bioinorganic chemistry's two major focuses:natu...
Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy
With contributions by numerous experts
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987
Global Seagrass Research Methods
This thorough and informative volume presents a set of detailed, globally applicable techniques for seagrass research.The book provides methods for all aspects of seagrass science from basic plant collection to statistical approaches and investigations of plant-animal interaction. The emphasis is on methods that are applicable in both developing and developed countries. The importance of seagrasses in coastal and near shore environments, and ultimately their contribution to the productivity of the world's oceans, has become increasingly recognised over the last 40 years.Seagrasses provide food for sea turtles, nearly 100 fish species, waterfowl and for the marine mammals the manatee and dugo...
Transition Metal Complexes as Drugs and Chemotherapeutic Agents
When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica tion of the manuscript. The introduction contains an explanation of the layout and approach to the book, which I wrote as an overall survey of the wide variety of biological properties of metal complexes. Hopefully, the reader will see the parallels in mechanisms and behavior, even in different organisms. The writing was considerably helped by the enthusiasm and confidence (totally unearned on my part) in ...
Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or ...
Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment
Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.
Vegetation of inland waters
By 1988 the Handbook of Vegetation Science is well on its way to completion. With 7 volumes in circulation, 3 volumes in the press, and most of the remaining volumes in preparation it appears that the total task can be completed in the early 'nineties. I am especially thankful to Professor Symoens for accepting the task of editing the volume on aquatic vegetation. The main emphasis of work in phytosociology is devoted to land plants, yet the landscape analysis remains incomplete without the consideration of rivers and lakes. Avolume on inland aquatic vegetation must therefore be most helpful to the land vegetation analyst and not only to the specialist on aquatic vegetation. Professor Symoen...
