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The Porphyrins V6
The Porphyrins, Volume VI: Biochemistry, Part A deals with the biochemistry of porphyrins, their precursors, catabolic derivatives, and related compounds. The book covers the biosynthesis of porphyrins and chlorophylls; the formation and metabolism of bile pigments in animals and plants; as well as the synthesis, characterization, and chemistry of the bile pigments and their derivatives. An account of the historical and clinical aspects of porphyrins and bile pigments is also given. This volume is organized into 12 chapters and begins with an overview of protoporphyrins and their metabolic intermediates, paying particular attention to their synthesis and biosynthesis. The discussion then shi...
Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders
Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).
Human Stefins and Cystatins
This book brings up-to-date information on developments in studies of human stefins and cystatins, proteins with the function of cystein proteases (cathepsins) inhibition. The chapters start at the level of genes, go on with protein structure and function (proposal of alternative function), protein stability and folding, to mis-folding and mis-function. The book ends with chapters describing different disease states where stefins or cystatins are involved, from Alzheimer's disease, epilepsy to cancer.
Debating Lapita
‘This volume is the most comprehensive review of Lapita research to date, tackling many of the lingering questions regarding origin and dispersal. Multidisciplinary in nature with a focus on summarising new findings, but also identifying important gaps that can help direct future research.’ — Professor Scott Fitzpatrick, Department of Anthropology, University of Oregon ‘This substantial volume offers a welcome update on the definition of the Lapita culture. It significantly refreshes the knowledge on this foundational archaeological culture of the Pacific Islands in providing new data on sites and assemblages, and new discussions of hypotheses previously proposed.’ — Dr Frédéri...
Proteases as Targets for Therapy
This volume is the first to combine latest information on viral, microbial and cellular proteolytic enzymes as potential targets for human therapeutics. Proteases control a large array of physiological reactions, and are involved in a variety of pathological processes for which effective medications are currently needed and/or being sought after. Although protease inhibitors have been investigated for many years, few have been employed therapeutically. Recent break- through by HIV protease inhibitors as therapeutic drugs has re-encouraged the search for inhibitors of other proteolytic enzymes. Klaus von der Helm, who described the first viral protease has brought leading experts together to discuss not only the success and problems of clinical use and continuing prospects, but to review further potential drug targets. This volume provides detailed information and evaluations of key viral, bacterial, fungal, and cellular proteases as potential future drug candidates.
Handbook of Neurochemistry
Anyone who has any contact with mental patients, old or young, or their families, or just visits a mental hospital or school for the retarded, is aware of the tremendous suffering caused by malfunctioning of the brain. The func tion of no other organ is so crucial for our everyday life, our proper func tioning, indeed our happiness, and no other illness causes as much anguish to patients or their families as mental illness. It is surprising and sad, therefore, how little effort has been devoted to research in this area; more so because such research is the only hope to ameliorate this suffering, or, to speak in the language of politics or economics, to decrease the enormous sums that we spen...
Humour in the Beginning
Humour in the Beginning presents a multidisciplinary collection of fourteen in-depth case-studies on the role of humour – both benign and blasphemous, elitist and ordinary, orthodox and heterodox – in early, formative stages of Christianity, Islam, Buddhism, Hinduism and (late-antique) Judaism. Its coherence is strengthened by four preceding theoretical essays, many cross-references and a conclusion. Thus, the volume allows for a methodologically sound comparison and explanation of historical views on humour in the world’s most important religions. At first sight, the foundational period of religions do not seem to offer much opportunities for humour. A closer look on primary sources, however, reveals the ways in which people formulated answers to existing ideas on humour and laughter, in moments of religious renewal. Main topics include the incongruous nature of the divine, the role of anthropomorphism, superior and didactic humour, moderate laughter, responses from dissenters and the gap between religious regulations and reality.
Micro-Mesoporous Metallosilicates
Micro-Mesoporous Metallosilicates Up-to-date and in-depth text bridging the technology gap between fundamental research and industry-scale applications of porous materials for catalysis Micro-Mesoporous Metallosilicates: Synthesis, Characterization, and Catalytic Applications comprehensively introduces the chemistry and catalytic technologies of metallosilicates, an important family of microporous crystalline zeolite and heteroatom-containing mesoporous materials, with a primary focus on design synthesis, characterization, theoretical studies, and catalytic applications of titanosilicates, tin-silicates, germanosilicates and Ti-mesosilica, and more. The text covers recent advances in the syn...
Quantification of Biophysical Parameters in Medical Imaging
This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.
