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“What is Horvath’s/Epigenetic Clock? Understanding the first-ever accurate Age Predictor…”
“What is Horvath’s/Epigenetic Clock? Understanding the first-ever accurate Age Predictor…” Greying hair and wrinkles are external signs of ageing, but they are not very precise. Now research shows that a code written into the body's epigenome — the chemical tags that modify DNA — can accurately tell the age of human tissues and cells. This ‘clock’ innovated by Steve Horvath could provide insights into why certain tissues age faster than others, and why those tissues may be more cancer-prone. In the past few years, researchers have been homing in on regions of DNA that accrue lots of chemical tags called methyl groups as people age. Such methylation can selectively switch off ...
Drug Design
Drug Design, Volume III covers the mode of action of biologically active compounds. The book discusses microbial transformations that have been used in the preparation of drugs or closely related substances; the use of linear free energy parameters and other experimental constants in structure-activity studies; and the mode of action of anticoagulants structurally and functionally related to vitamin K. The text also describes the design of beta-blocking drugs, biologically active acridines, local anesthetics, and insect chemosterilants. The molecular approach for designing inhibitors to enzymes involved in blood clotting is also considered. Chemists, pharmacologists, and people involved in drug design.
International Arbitration and International Commercial Law
Over the last half-century, as UNCITRAL official, professor, arbitrator and father of the Willem C. Vis Arbitration Moot, Eric Bergsten has been at the forefront of progress in international commercial arbitration. Now, on the occasion of his eightieth birthday, the international arbitration and sales law community has gathered to honour him with this substantial collection of new essays on the many facets of the field to which he continues to bring his intellect, integrity, inquisitive nature, eye for detail, precision, and commitment to public service. Celebrating the long-standing and sustained contribution Eric Bergsten has made in international commercial law, international arbitration,...
The Essence of Chromatography
The Essence of Chromatography presents a comprehensive survey of modern chromatography and is intended as a suitable text for graduate level courses in the separation sciences and as a self-study guide for professional chromatographers wishing to refresh their background in this rapidly expanding field.This title is an effective replacement for Chromatography Today, written by the same author with Salwa K. Poole, which is considered to be one of the definitive chromatographic texts of the last decade. Its format is modular, with extensive cross-references to permit rapid location of re.
Non-crystalline And Nanoscale Materials - Proceedings Of The Fifth International Workshop On Non-crystalline Solids
This workshop is the fifth in a series devoted to the presentation and discussion of new findings in the field of noncrystalline solids such as amorphous and nanocrystalline materials, granular systems and fine particles, multiphase systems and thin films, polymers, and other disordered systems. The workshop is divided into six categories, with ten invited contributions.
Personality Disorders
This work offers an evaluation of competing theoretical perspectives and nosological systems for personality disorders. The editors have brought together recognized authorities in the field to offer a synthesis of competing perspectives that provide readers with an assessment for each disorder. The result is a comprehensive, current, and critical summary of research and practice guidelines related to the personality disorders. Key Features focuses on controversies and alternative conceptualizations; separate chapters are dedicated to each personality disorder and considered from various points of view. It presents authoritative perspectives; leading scholars and researchers in the field prov...
