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Insights into Receptor Function and New Drug Development Targets
This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.
House Documents
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Orthopaedic Trauma Surgery
This book adopts the principle of guiding surgery by anatomy, fixation by biomechanics, and clinical procedures by functional recovery. In each chapter, the applied anatomy of the fracture site is first introduced, which confers prominence to the relationship between the anatomical structure and surgery and emphasizes the structure that must be protected and repaired during surgery. In addition, the biomechanical characteristics of the fracture site are described, so that the appropriate fixation method can be selected according to the characteristics of the mechanical environment. In most chapters on periarticular fractures, the book also describes in detail how the joints fulfil their func...
Assessments of Regional and Global Environmental Risks
As environmental challenges grow larger in scale and implications, it is increasingly important to apply the best scientific knowledge in the decisionmaking process. Editors Farrell and Jäger present environmental assessments as the bridge between the expert knowledge of scientists and engineers on the one hand and decisionmakers on the other. When done well, assessments have a positive impact on public policy, the strategic decisions of private firms, and, ultimately, the quality of life for many people. This book is the result of an international, interdisciplinary research project to analyze past environmental assessments and understand how their design influenced their effectiveness in ...
Orthobiologics
Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by internationally renowned experts Drs. Scott P. Bruder and Roy K. Aaron, Orthobiologics: Scientific and Clinical Solutions for Orthopaedic Surgeons provides authoritative, comprehensive coverage of this fast-growing field. This one-stop reference is an ideal resource, covering technology and basic science through specific clinical applications.
The Dark Social
This book explores how people interact online through anonymous communication in encrypted, hidden, or otherwise obscured online spaces. Beyond the Dark Web itself, this book examines how the concept of ‘dark social’ broadens the possibilities for examining notions of darkness and sociality in the age of digitality and datafied life. The authors take into account technical, moral, ethical, and pragmatic responses to ourselves and communities seeking to be/belong in/of/ the dark. Scholarship on the Darknet and Dark Social Spaces tends to focus on the uses of encryption and other privacy-enhancing technologies to engender resistance acts. Such understandings of the dark social are naturall...
Physiology of the Gastrointestinal Tract
FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tractto collect in one set of volumes the most current and comprehensive knowledge in our fieldwas also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignanci...
Infectious Diseases and Nanomedicine I
The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a first volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal. The book focuses mainly on the topics: emerging infectious diseases; antimicrobial agents, vaccines and immunity; drug design, drug delivery and tissue engineering and nanomaterials and biomedical materials.
