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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
This book constitutes the thoroughly refereed post-conference proceedings of the 21st Japanese Conference on Discrete and Computational Geometry and Graphs, JCDCGGG 2018, held in Quezon City, Philippines, in September 2018. The total of 14 papers included in this volume was carefully reviewed and selected from 25 submissions. The papers feature advances made in the field of computational geometry and focus on emerging technologies, new methodology and applications, graph theory and dynamics.
Former Suburban area included in vol. 2.
List of members in each volume.