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The Pathology of the Human Placenta
This presentation of the diseases of the placenta differs in many ways from the first such treatment in these volumes by the eminent Robert Meyer. It is a deliberate attempt to bring together the practical information which has been gathered about the pathology of this complex organ and to make it available to the practicing pathologist as well as clinician. Despite the ready availability of the placenta for study, the pathologist is often ill-prepared to interpret lesions which he may find. Moreover, it has been difficult for him to find reference material, published commonly in journals and books with which he is not familiar. Further more, the interpretation of lesions affecting the place...
Occupational Asthma
Recent developments in occupational asthma research and clinical practice are the focus of this publication. It discusses the contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults, powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures, and diagnostic criteria for work related and work aggravated asthma. Specific emphasis is given to exposure response relationships for allergen exposure, large gene-environment studies and whole genome screening approaches. Management, prevention and surveillance are covered as well. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes. Issues in the design of population studies are discussed to assist the readers in designing and conducting their own study. This comprehensive volume presents new developments changing the occupational asthma field in the coming years.
Algebraic Varieties: Minimal Models and Finite Generation
The finite generation theorem is a major achievement of modern algebraic geometry. Based on the minimal model theory, it states that the canonical ring of an algebraic variety defined over a field of characteristic zero is a finitely generated graded ring. This graduate-level text is the first to explain this proof. It covers the progress on the minimal model theory over the last 30 years, culminating in the landmark paper on finite generation by Birkar-Cascini-Hacon-McKernan. Building up to this proof, the author presents important results and techniques that are now part of the standard toolbox of birational geometry, including Mori's bend and break method, vanishing theorems, positivity theorems and Siu's analysis on multiplier ideal sheaves. Assuming only the basics in algebraic geometry, the text keeps prerequisites to a minimum with self-contained explanations of terminology and theorems.
Difficult To Treat Asthma
This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintai...
Exposure
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Asthma and COPD
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
