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An investigation of microRNA target regulation mechanisms using an integrative approach
This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.
Blood
Following its highly successful and well-respected first edition, this thoroughly revised edition offers much more! Edited and authored by leading authorities in hematology, this scientific reference textbook now comes with a CD-ROM. Additional features include some of the more salient standard and current therapeutics and an easily accessible appendix that provides great reference. The CD-ROM contains 100 of the most critical illustrations from the text—great for quick consultation from your computer.
From Local Invasion to Metastatic Cancer
In human solid tumors, nodal status is the most important prognostic indicator for patient outcome. Recent developments in the sentinel lymph node concept have resulted in new procedures to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites Through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important development...
Glucose Metabolism in the Brain
Regulation of glucose at the biochemical level affects every area of the brain, and has impact from cellular to behavioral brain function. It plays an important role in diseases such as diabetes, stroke, schizophrenia and drug abuse as well as in normal and dysfunctional memory and cognition. This volume represents a thorough examination of all the major issues that are relevant to glucose metabolism by brain cells in relation to disease, combining basic research and clinical findings in a single, indispensable reference. Key Features * Serves as an essential reference on glucose metabolism in the brain * Presents authoritative accounts by leading researchers in the field * Includes thorough reviews with provocative sections on future directions
A Course on the Web Graph
"A Course on the Web Graph provides a comprehensive introduction to state-of-the-art research on the applications of graph theory to real-world networks such as the web graph. It is the first mathematically rigorous textbook discussing both models of the web graph and algorithms for searching the web. After introducing key tools required for the study of web graph mathematics, an overview is given of the most widely studied models for the web graph. A discussion of popular web search algorithms, e.g. PageRank, is followed by additional topics, such as applications of infinite graph theory to the web graph, spectral properties of power law graphs, domination in the web graph, and the spread of viruses in networks. The book is based on a graduate course taught at the AARMS 2006 Summer School at Dalhousie University. As such it is self-contained and includes over 100 exercises. The reader of the book will gain a working knowledge of current research in graph theory and its modern applications. In addition, the reader will learn first-hand about models of the web, and the mathematics underlying modern search engines."--Publisher's description.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Ischia Group Theory 2004
Experts in the theory of finite groups and in representation theory provide insight into various aspects of group theory, such as the classification of finite simple groups, character theory, groups with special properties, table algebras, etc. Information for our distributors include: This book is co-published with Bar-Ilan University (Ramat-Gan, Israel).
On-Line Hemodiafiltration: The Journey and the Vision
On-line HDF represents a major technical development in the delivery of hemodialysis therapy: It combines the properties of increased diffusion available in current high-flux membranes with convective removal of between 6 and 30 liters per treatment and requires the use of ultrapure water and online filtration of replacement fluid. On-line HDF has been successfully introduced in Europe and Asia and is routinely prescribed for dialysis patients in these regions.The book at hand summarizes the history and achievements of on-line HDF in four parts: A report of the technological development in both machine and fiber/dialyzer is followed by a description of the challenges encountered in the evolution of on-line HDF, collecting the accounts of clinical key opinion leaders who had been involved in its early application. The third part presents a comprehensive review of the clinical results achieved with on-line HDF from its inception to the present times, in which it represents the clinical golden standard. The fourth and final part is dedicated to on-line HDF as a ‘vision’ for the future.
Geological Mapping of Our World and Others
Map-making is a fundamental tool for developing geological knowledge. It involves data collection and interpretation and has its roots in the earliest discoveries in Earth science. It is the starting point for stratigraphic and structural interpretations, metamorphic facies, geochronology and modelling studies – and underpins civil engineering. From the beginning, geological mapping rapidly evolved into far more than being a simple spatial catalogue of observable rock types and landforms on the Earth’s land-surface: deductive reasoning allows this knowledge to infer subsurface Earth structure. However, the same approaches have also been down-scaled to deduce processes on the grain-scale; or up-scaled to look out to extraterrestrial objects. This Special Publication draws together these strands, crossing geoscience disciplines and observation scales to celebrate geological mapping, its historical importance and future directions, and its use in applied geology together with developing knowledge of Earth and planetary evolution and processes.
