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The American Hatter
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Endoplasmic Reticulum
In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. Coverage includes protein translocation and export, lipid metabolism, antigen presentation, and many other subjects, gleaned from such diverse fields as cell biology, enzymology and membrane biochemistry, immunology, and signal transduction.
Methods of Hybridoma Formation
Laymen often consider modern laboratory research to be based on an endless array of sophisticated technologies whose complex capabilities are as important to the outcome of any project as the inventiveness and creativity of the scientists who employ them. Scientists at times may share this point of view until they are con fronted by unexpected findings that demand new approaches, and they discover that yesterday's "sophisticated tools" are today's "blunt instruments." This experience provides a more sobering view of the current state of our scientific methods. It also serves as an impetus for the further development of technology that prepares us for the next stage of advance. Immunologists ...
Etiology of Acute Leukemias in Children
Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theories and hypothesis regarding childhood acute leukemia. Written by the most outstanding researchers in the field, this book intends to contribute to a greater understanding of the etiology of this disease. It goes beyond the simple and common analysis of risk factors, which hardly allows us to draw definite conclusions. By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children. The knowledge regarding etiology is a crucial step for a better evaluation, prevention and treatment of a disease. Thus, this book finally intends to provide such knowledge, allowing physicians and practitioners to a better manage of childhood acute leukemias.
More Than Just Grit
Much of Civil War history emphasizes generalship (or the lack of it) as the key factor in analyzing why battles were won or lost. Taking an innovative approach, this book focuses on six elements of victory in nine important Western Theater engagements during 1862--a year when the North had not yet fully mobilized for war. With increasing complexity on the battlefield and the enormous growth of American armies, winning or losing depended upon achieving as many of these six critical goals as possible: a clear objective; mobilization of effective lieutenants; a competent staff; seizing and holding initiative; deploying all available resources; and realizing a successful strategic outcome. The more goals achieved, the greater the victory.
