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Beginning with an introduction to kidney function, renal replacement therapies, and an overview of clinical problems associated with haemodialysis, this book explores the principles of the short-term baroreflex regulation of the cardiovascular system and the mechanisms of water and solute transport across the human body from a mathematical model perspective. It synthesizes theoretical physiological concepts and practical aspects of mathematical modelling needed for simulation and quantitative analysis of the haemodynamic response to dialysis therapy. Including an up-to-date review of the literature concerning the modelled physiological mechanisms and processes, the book serves both as an ove...
Peritoneal dialysis (PD) has been widely used in renal replacement therapy (RRT) for end-stage kidney disease (ESKD) and acute kidney injury (AKI) because of its convenience, home implementation, no need for large equipment, and its alignment with human physiology. Around 11% of patients with kidney failure worldwide are treated with PD. Although some progress has been made in the research of PD devices, technology and peritoneal dialysate biocompatibility in recent years, there are several limitations. Of major concern is the infectious complications. Another limitation is the ion transport ability of PD. On the one hand, the ability to remove the uremic toxin and water is far below physiol...
Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plas...
Illustrated in full colour throughout, this comprehensive edition provides the reader with complete information on clinical and practical problems in nephrology.
This volume collects papers based on lectures given at the XXXIX Workshop on Geometric Methods in Physics, held in Białystok, Poland in June 2022. These chapters provide readers an overview of cutting-edge research in geometry, analysis, and a wide variety of other areas. Specific topics include: Classical and quantum field theories Infinite-dimensional groups Integrable systems Lie groupoids and Lie algebroids Representation theory Geometric Methods in Physics XXXIX will be a valuable resource for mathematicians and physicists interested in recent developments at the intersection of these areas.
Hemodialysis (HD) represents the first successful long-term substitutive therapy with an artificial organ for severe failure of a vital organ. Because HD was started many decades ago, a book on HD may not appear to be up-to-date. Indeed, HD covers many basic and clinical aspects and this book reflects the rapid expansion of new and controversial aspects either in the biotechnological or in the clinical field. This book revises new technologies and therapeutic options to improve dialysis treatment of uremic patients. This book consists of three parts: modeling, methods and technique, prognosis and complications.
Volume I of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. The chapters are thematically organized into the following main areas: cellular biophysics, regulatory networks, developmental biology, biomedical applications, data analysis and model validation. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.
First multi-year cumulation covers six years: 1965-70.