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Brain Somatic Cross-Talk and the Central Control of Metabolism
In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.
Perspectives on Vasopressin
Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours. This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotransmitter. A consideration of the evolution of the molecule across the species and a brief historical ...
From Biotechnology to Genomes
Aimed at scientists and non-specialised readers alike, this book retraces the source of national and international biotechnology programmes by examining the origins of biotechnology and its political and economic interpretation by large nations. With a foreword by Andr(r) Goffeau, who initiated the European Yeast Genome Project, the book describes the achievements of the first genetic and physical maps, as well as the political and scientific genesis of the American Human Genome Project. Following these advances, the author discusses the European biotechnology strategy, the birth and implementation of European biotechnology programmes and the yeast genome project.
Aminergic and Peptidergic Receptors
Advances in Pharmacological Research and Practice, Volume VII: Aminergic and Peptidergic Receptors focuses on how neurotransmitters, drugs, and hormones affect the plasma membrane. Composed of 14 chapters, the book outlines the manner by which presynaptic receptors involved in chemical neurotransmission function. The text then presents various laboratory experiments done to animals to determine how these receptors affect the plasma membrane of these subjects. One of the internal body parts examined is the heart. The variation in sensitivity of opiate receptors is also discussed, focusing on the effect of opioid peptides and morphine on the nigrostriatal axon terminals. The book also discusses the biochemical and pharmacological assets of opiate receptors among mollusks; the upshot of peptides upon biogenic amines of the central nervous system; and how gastrin analogues affect the gastrin receptor of the stomach. This book is a great find for highly trained scholars in the field of receptor research, including biochemists, chemists, pathologists, morphologists, physiologists, and pharmacologists.
Phosphodiesterase Inhibitors
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. - Utilizes actual testing and research of new PDE inhibitors - Valuable for researchers and students alike
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