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Idiotypes
Idiotypes documents the proceedings of an International Conference on Idiotypes held in Oklahoma City, Oklahoma, at the Oklahoma Medical Research Foundation, October 20-23, 1985. The aims of the conference were to gather active investigators in the study of idiotypes; to assess progress in the field; and to explore directions for future research. The papers presented at the conference cover a wide range of subjects. Several papers deal with defining protein and DNA sequences which determine idiotypes. Evidence points to germ line genes encoding the V region structures which underlie idiotypy. Another subtheme which concerns several contributions is the occurrence of dominant idiotypes in ind...
The Captors' Narrative
The author reconstructs the lived experience of both captors and captives to show that captivity was always intertwined with gender struggles, providing a novel perspective on the struggles over female authority pervasive in colonial America.
The Antibodies
From diagnostic tools to therapy against cancer, infections and autoimmune diseases, antibodies serve many purposes, yet our knowledge of them is still incomplete. The Antibodies: Volume 7 continues with a comprehensive review of topics of contemporary interest including major breakthroughs such as the advent of monoclonal antibodies and the develo
The Network Collective
The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated an entire generation of young immunologists. But fascination led to experimental errors and overinterpretation, eventually magnifying the immune system from a mere infection-fighting device to a substrate of personality and individuality. As a result, what initially appeared as an ...
Dendritic Cells in Fundamental and Clinical Immunology
These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi cal areas has been heatedly discussed.
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In Vivo Immunology
The 11th International Conference on Lymphoid Tissues and Immune Reactions was held in Spa-Liege (Belgium), from 4 to 8 July 1993. The regular devotees refer to these conferences as the "Germinal Centre Conferences or GCC". In the 1960s, the germinal centres were the subject of such considerable study and speculation that a group of dynamic people decided to devote an international conference centered on that topic. This led to the fIrst GCC organized in Bern in 1966. Following the success of this initial meeting, further sessions have been organized at regular intervals and, over the years, the scope of the GCC has been broadened. Nowadays, the GCC conferences are dedicated to in vivo immun...
Revolution in the House
To what extent did the French Revolution "revolutionize" the French family? In examining the changes in inheritance laws brought on by the Revolution, Margaret Darrow gives a lively account of the mixed effects legislation had on families of this period. As a test case, she has chosen the southern city of Montauban, whose Roman-based law enabling testators to appoint their heirs was contradicted by the new laws instituting equal inheritance. Filled with vivid anecdotes, this book shows how Montauban families in varying social classes adapted their financial strategies to cope with rapidly shifting circumstances, often creating solutions not envisioned by the legislators. With family history ...
