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Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.
A new class of immune cells has been recently identified. These lymphocytes belong to Innate Immunity as they do not express antigen-specific receptors, and are hence referred as to Innate Lymphocytes cells (ILCs). The developmental and functional properties of ILC are reminiscent of several T cell subsets, making them possible innate counterparts of these adaptive lymphocytes. Understanding the biological functions of these cells is a current fixation for immunologists, microbiologists and clinicians, as ILCs might be involved in several features of immune responses that have remained poorly understood. This volume of CTMI is dedicated to ILC biology and aims to broaden our understanding of the role of these new players in immune responses. Prominent scientists in the field will review exhaustively the key recent research into ILCs from their developmental origins to their potential roles in the maintenance of tissue integrity and in pathological conditions.
The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS
Dieses Fachbuch erläutert die molekularen Grundlagen von Entzündungen, spannt den Bogen zu Infektionskrankheiten und den Zusammenhang zwischen Entzündungen und chronischen Erkrankungen, behandelt abschließend den Heilungsprozess und zeigt Therapiemöglichkeiten.
To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.
The Congressional Record is the official record of the proceedings and debates of the United States Congress. It is published daily when Congress is in session. The Congressional Record began publication in 1873. Debates for sessions prior to 1873 are recorded in The Debates and Proceedings in the Congress of the United States (1789-1824), the Register of Debates in Congress (1824-1837), and the Congressional Globe (1833-1873)