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Growing Bone
Growing numbers of men and many more women are suffering from crippling bone loss called osteoporosis. By 2050 50% of Americans over 50 will be at risk of, or actually have, osteoporosis. In this book the reader will meet the newest real and possible bone builders and learn how they might work. These include novel steroids, an osteogenic growth pep
Growing Bone, Second Edition
Growing numbers of men and many more women are suffering from crippling bone loss called osteoporosis. By 2050 50% of Americans over 50 will be at risk of, or actually have, osteoporosis. In this book the reader will meet the newest real and possible bone builders and learn how they might work. These include novel steroids, an osteogenic growth peptide (OGP), leptin from both fat cells and osteoblasts and the many kinds of statin that are widely used to reduce blood cholesterol and seem to prevent Alzheimer’s disease. But the spotlight must be directed onto the currently most promising bone growers, the 84-amino acid parathyroid hormone (PTH) and three of its 31- and 34-amino-acid fragments.
Anabolic Treatments for Osteoporosis
Osteoporosis, a growing epidemic among women in North America, Europe, and Japan, is a painful, costly disease that has presented a treatment challenge to healthcare professionals. Until recently, therapies have focused on agents that slow bone resorption, and have had only limited success at increasing bone mass.
Calcium
This volume provides a lucid state-of-the-art tour of the critical signaling roles calcium plays in both the normal and carcinogenic cell cycles of proliferation, differentiation, and death. Whitfield and Chakravarthy (Institute for Biological Sciences, National Research Council of Canada, Ottawa) commence their discussion with the intriguing comment that no revolution has had as much an impact on Earth as the Great Calcium-Driven Eukaryotic Revolution occurring soon after the planet's birth. The final chapter explains how calcium also drives responsiveness in plants. Includes exceptionally well-referenced chapters, crisp color graphics, and a bilingual French-English abstract. Annotation copyrighted by Book News Inc., Portland, OR.
Calcium in Cell Cycles and Cancer
The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine." The book also shows calcium to be a terminal, ultimately apoptogenic differentiator of colon and skin cells, as well as a major player in lymphocyte selection, activation, and proliferation. This edition relates and explains the dramatic changes in calcium's involvement in the cell cycle and the triggering of terminal differentiation programs that happen during carcinogenesis and are important keys to understanding cancer.
Ions, Cell Proliferation, and Cancer
Ions, Cell Proliferation, and Cancer present the credibility of ions as specific regulators of cell proliferation. This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell functions. This text then examines the relationship between ionic events and cellular production, specifically in mammalian cell systems. Other chapters consider the development of atomic absorption spectrophotometry as a method for measuring inorganic cations. This book discusses as well the two widely applicable methods for measuring free concentrations of ions inside cells. The final chapter deals with magnesium ion as the most abundant divalent action in living cells. This book is a valuable resource for animal cell biologists, molecular biologists, and research workers.
Malignant Cell Secretion
First Published in 1990, this book offers a full, comprehensive guide into the nature of cells. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, Microbiology, and other practitioners in their respective fields.
Calcium
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Calcium, Cell Cycles, and Cancer
Whitfield (head of the cellular oncology group of the National Research Council of Canada) provides a critical and comprehensive survey of the known relationships between calcium, cell cycles, and cancer. A major theme is that calcium works with the regulator, cyclic AMP, to send five distinct signals that trigger the cycle ending in the cell's nuclear reconstruction. This is demonstrated through in- depth examinations of various cell cycles. On this foundation, he presents an extensive discussion of the changes in the signaling mechanisms and the loosening of their hold on cell cycle events that are key parts of the multistage carcinogenic process. Of interest to biochemists, cell biologists, pharmacologists, physiologists, and clinicians. Annotation copyrighted by Book News, Inc., Portland, OR
