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Jan Hendrik Hofmeyr
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Philosophy of Systems Biology
The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers,...
Methods in Systems Biology
Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research. - This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology - With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research
Systems Biology
For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.
Information and Living Systems
The informational nature of biological organization, at levels from the genetic and epigenetic to the cognitive and linguistic. Information shapes biological organization in fundamental ways and at every organizational level. Because organisms use information--including DNA codes, gene expression, and chemical signaling--to construct, maintain, repair, and replicate themselves, it would seem only natural to use information-related ideas in our attempts to understand the general nature of living systems, the causality by which they operate, the difference between living and inanimate matter, and the emergence, in some biological species, of cognition, emotion, and language. And yet philosophe...
New Beer in an Old Bottle. Eduard Buchner and the Growth of Biochemical Knowledge
We should commemorate the centenary of Buchner’s discovery not only because of its inherent importance and interest, but also because vitalist ways of thinking have by no means disappeared, and modern biologists need to be constantly on their guard agaisnt them. Far worse than vitalism, which in Pasteur’s hands was, after all, based on rational interpretation of apparently coherent observations, the past few decades have seen the return of obscurantist mysticism in the formo f socalled “creation science” and other abuses of the intellect. Forgetting the history of biology is no way to combat these, ant they provide another reason why it is worthwhile to recall how our current ideas cam into existence.
Metaphysical Emergence
Metaphysical Emergence provides a detailed analyses of two ways for phenomena to be grounded in and yet distinct from underlying physical reality, and brings this to bear on a number of live debates in metpahysics, including those concerning consciousness and free will.
The Humanist Imperative in South Africa
This book is an outcome of the conversation that occurred during the five days of intense discussion at two symposia initiated by the New Humanism Project. The struggle for a more humane society is both local and universal, and increasingly these are connected in our time. So while the conversation focused specifically on South Africa, the discussion was neither parochial nor insular in its scope and character. Hopefully, then, people beyond South Africa will find the contents of this book of value for them in terms of their own contexts.
From the Atom to Living Systems
From the Atom to Living Systems represents an original historico-epistemological approach to follow the passage, in the microscopic analysis of reality, from the atomic to the molecular to the macromolecular levels and then to the threshold of life itself. Naturally, some parts of this journey have been developed in other works, some highly specialized and others of a more general nature. However, although this journey has often been traced in specialized scientific detail, the philosophical implications of the journey have not been discussed to any satisfactory degree. This scientific journey does have important philosophical consequences that constitute an integral part of this book, which...
