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The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers,...
Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research. - This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology - With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research
For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.
The informational nature of biological organization, at levels from the genetic and epigenetic to the cognitive and linguistic. Information shapes biological organization in fundamental ways and at every organizational level. Because organisms use information—including DNA codes, gene expression, and chemical signaling—to construct, maintain, repair, and replicate themselves, it would seem only natural to use information-related ideas in our attempts to understand the general nature of living systems, the causality by which they operate, the difference between living and inanimate matter, and the emergence, in some biological species, of cognition, emotion, and language. And yet philosop...
Both the special sciences and ordinary experience present us with a world of macro-entities - trees, birds, lakes, mountains, humans, houses, and sculptures, to name a few - which materially depend on lower-level configurations, but which are also distinct from and distinctively efficacious ascompared to those configurations. This give rise to two key questions. First, what is metaphysical emergence, more precisely? Second, is there actually any metaphysical emergence? Metaphysical Emergence provides clear, compelling, and systematic answers to these questions. Wilson argues that thereare two and only two forms of metaphysical emergence that make sense of the target cases: 'Weak' emergence, ...
THIS BOOK collects together papers given at a NATO Advanced Research Workshop held at Il Ciocco (Lucca), Italy, from the 9th to the 15th April, 1989. It sets out to present the current state of understanding of the principles governing the way fluxes and concentrations are maintained and controlled in metabolic systems. Although this is a topic that has held the interest of biochemists for many years, it is only quite recently that the methods of analysing the kinetics of multi-enzyme pathways developed over the past two decades have come to be widely discussed or applied experimentally. Many biochemists remain sceptical that the new methods offer a real advance (except in complexity) over t...
This book is an outcome of the conversation that occurred during the five days of intense discussion at two symposia initiated by the New Humanism Project. The struggle for a more humane society is both local and universal, and increasingly these are connected in our time. So while the conversation focused specifically on South Africa, the discussion was neither parochial nor insular in its scope and character. Hopefully, then, people beyond South Africa will find the contents of this book of value for them in terms of their own contexts.
From the Atom to Living Systems represents an original historico-epistemological approach to follow the passage, in the microscopic analysis of reality, from the atomic to the molecular to the macromolecular levels and then to the threshold of life itself. Naturally, some parts of this journey have been developed in other works, some highly specialized and others of a more general nature. However, although this journey has often been traced in specialized scientific detail, the philosophical implications of the journey have not been discussed to any satisfactory degree. This scientific journey does have important philosophical consequences that constitute an integral part of this book, which...