You may have to Search all our reviewed books and magazines, click the sign up button below to create a free account.
None
Biochemical Actions of Hormones, Volume XI is a 12-chapter text that covers the general and specific biochemical aspects of polypeptide and steroid hormones. The introductory chapters deal with the biochemical actions of the leukotrienes, the cyclic adenosine monophosphate, and the gonadotropin releasing hormone. The next chapters highlight detailed contributions on polypeptide hormone research. These chapters specifically tackle the insulin actions and the role of insulin in mammary gland development. The last series of chapters on steroid hormones includes X-ray crystallographic analysis of steroid structures and the significance of these studies on steroid-receptor interactions. These chapters also explore the analysis of the estrogen receptor with monoclonal antibodies; the role of estrogen receptor in responsive mammalian cells; the use of peroxidase as a marker of catechol estrogen action; and the activation and stabilization of the glucocorticoid receptor. This volume will be of great benefit to biochemists, biologists, endocrinologists, and researchers who are interested in the hormonal action and regulation.
model. In general, the mean atomic positions and the geometrical parameters calculated from them are more accurate if the more sophisticated anisotropic model has been used for the thermal motion during structure refinement. Low temperature data collection also results in more accurately determined structures. By decreasing the temperature at which data is collected, the intensities and number of data observed is increased. Since hydrogen atoms have only a single electron, they scatter X-rays very weakly, and they can be observed experimentally only if the data are of good quality. Finally, in the absence of systematic errors in data collection or refinement, tae greater the number of observ...
First multi-year cumulation covers six years: 1965-70.
Biochemical Actions of Hormones, Volume XII is a compendium of papers discussing aspects of molecular biology with regard to hormone action and to certain hormone receptors. One paper discusses the different approaches and strategies that are used in determining the amino acid sequence. The paper also describes the structural organization of polyprotein precursors such as the peptide chemistry approach or the nucleic acid approach. Another paper investigates the regulation of prolactin biosynthesis by peptide hormones as a model for peptidergic regulation of gene expression. The paper defines in detail which components of the biosynthetic machinery are being regulated by the polypeptide horm...
This book leaves the conventional view of chemical structures far behind: it demonstrates how a wealth of valuable, but hitherto unused information can be extracted from available structural data. For example, a single structure determination does not reveal much about a reaction pathway, but a sufficiently large number of comparable structures does. Finding the 'right' question is as important as is the intelligent use of crystallographic databases. Contributions by F.H. Allen, T.L. Blundell, I.D. Brown, H.B. Bürgi, J.D. Dunitz, L. Leiserowitz and others, authoritatively discuss the structure correlation method as well as illustrative results in detail, covering such apparently unrelated subjects as * Bond strength relations in soldis * Crystal structure prediction * Reaction pathways of organic molecules * Ligand/receptor interactions and enzyme mechanisms This book will be useful to the academic and industrial reader alike. It offers both fundamental aspects and diverse applications of what will surely become a powerful branch of structural chemistry.