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Principles of Sex-based Differences in Physiology
Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers. This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.
Chronic Renal Disease
Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Q...
Sex and Gender Differences in Cardiovascular-Renal-Metabolic Physiology and Pathophysiology
Sex and Gender Differences in Cardiovascular-Renal-Metabolic Physiology and Pathophysiology: Sex, Gender and Function, the latest release in the Fundamentals of Physiology series, provides a fundamental overview on sex and gender differences in all aspects of physiology. The book shares information on sex and gender differences in a variety of topics in a single comprehensive volume. This book, published in association with the International Union of Physiological Sciences acts as a primer of information scientists can build upon with their own research in sex and gender-based research. - Discusses how sex contributes to human cardiovascular/renal/metabolic disease (i.e., sex steroids, chromosomes, genes) - Provides hot topics in sex/gender research - Written by global leaders in their field of expertise
Redox-Genome Interactions in Health and Disease
At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.
Experimental Design and Reproducibility in Preclinical Animal Studies
This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. The book addresses advanced undergraduates, graduate students and all scientists working with animals.
Handbook of Models for Human Aging
The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations
Sex-Specific Analysis of Cardiovascular Function
This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.
Sex Differences in Cardiovascular Physiology and Pathophysiology
Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women.
