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Mitogen Activated Protein Kinases
Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.
Digital Healthcare Empowering Europeans
The digitization of healthcare has become almost ubiquitous in recent years, spreading from healthcare organizations into the homes and personal appliances of practically every citizen. Thanks to the collective efforts of health professionals, patients and care providers as well as systems developers and researchers, the entire population of Europe is able to participate in and enjoy the benefits of digitized health information. This book presents the proceedings of the 26th Medical Informatics in Europe Conference (MIE2015), held in Madrid, Spain, in May 2015. The conference brings together participants who share their latest achievements in biomedical and health Informatics, including the ...
Joining Efforts to Improve Data Quality and Harmonization Among European Population-Based Cancer Registries
Population-based cancer registries are an essential information source for quantifying the impact of cancer in a population and its evolution, planning and evaluation of cancer control policies and healthcare systems. In the last decades, the information provided by cancer registries has improved dramatically in quality and quantity. Technological advances and record linkage have contributed to data improvement. Therefore, clinical data collected by cancer registries such as stage, treatment, co-morbidity, etc. contribute to treatment effectiveness assessment and identification of inequality in health care access at the population level. The reliability and utility of the information provided by cancer registries depend on the quality of the data collected. On the other hand, cancer registries' data harmonisation is crucial for data use and comparability.
Paediatric drug optimization for cancer medicines
The goal of the Paediatric drug optimization for cancer exercise was to develop a PADO priority list of formulations to be prioritized with a time horizon of 3–5 years, and a PADO ‘watch list’ containing promising candidates for investigation and development for children with a time horizon of 5–10 years. The PADO–cancer exercise enables alignment between funders, procurers, market-coordination entities, researchers, innovators, generics manufacturers, product development partnerships and regulators on priority products to be investigated and developed, as well as increasing efforts to tackle challenges in access to cancer medicines in LMICs.
Struggle in the Dark
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Choroid Plexus Tumor Protocol CPT-SIOP-2000 2nd Edt
Choroid plexus tumors are rare. The CPT-SIOP-2000 protocol was a comprehensive document including disease information, standard of care recommendation, an international registry, and a randomized treatment protocol. This book makes the protocol available to the public.
2021 WHO Classification of Pediatric Brain Tumors: A Final Wedding Between Morphology and Molecular Biology?
Tumors of the central nervous system (CNS) are a dramatic health problem due to their high morbidity and mortality in all ages. In the pediatric population, brain tumors constitute the second most common cancer diagnosed worldwide each year, accounting for approximately 25% of childhood cancers. Although there has been a moderate increase in survival rates for children with CNS tumors over the past decades, CNS tumors remain the second leading cause of cancer death in children less than 20 years of age. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5) was recently released. This builds on the 2016 WHO CNS tumor update,...
Essays on the arts and sciences
To celebrate the 270th anniversary of the De Gruyter publishing house, the company is providing permanent open access to 270 selected treasures from the De Gruyter Book Archive. Titles will be made available to anyone, anywhere at any time that might be interested. The DGBA project seeks to digitize the entire backlist of titles published since 1749 to ensure that future generations have digital access to the high-quality primary sources that De Gruyter has published over the centuries.
