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Human Pluripotent Stem Cell Derived Organoid Models
Human Pluripotent Stem Cell Derived Organoid Models, Volume 159 highlights recent and emerging advances that describe organoid differentiation protocols for the different organ systems that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, development and evolution. Specific chapters in this new release include Pluripotent stem cell derived gastric organoids, Pluripotent stem cell derived esophageal organoids, Pluripotent stem cell derived small intestinal organoids, Pluripotent stem cell derived colonic organoids, Pluripotent stem cell intestinal organoids with an Enteric Nervous System, Pluripotent stem cell derived airway organoids, Pluripotent stem cell derived alveolar organoids, and much more. Provides the first comprehensive collection of pluripotent stem cell derived organoid protocols Includes cutting-edge methods Presents methods that generate organoids from many organ systems
Stress Analysis for Creep
Stress Analysis for Creep focuses on methods on creep analysis. The book first ponders on the occurrence of creep in mechanical engineering components, including background to stress analysis for creep and general-purpose computer programs for creep analysis. The text presents a phenomenological description of creep. The phenomenon of creep, physical mechanisms of creep, convenient uniaxial constitutive relationships, and creep rupture are described. The book also explains simple component behavior, creep under multiaxial states of stress, and stress analysis for steady creep. The text focuses on reference stress methods in steady creep. Reference stresses for combined loading with a power l...
Translational Research and Discovery in Gastroenterology
Translational Gastroenterology: Organogenesis to Disease bridges the gap between basic and clinical research by providing information on GI (gastrointestinal) organ development discovered through scientific inquiry, alongside clinical observations of acquired and congenital abnormalities. Paired chapters, written from basic science and clinical viewpoints, review the major biological pathways and molecules at work in organ ontogeny and disease. In addition to a comprehensive survey of GI organ development and pathologies, the book also highlights model organisms and new areas of research, with chapters devoted to recent advances in the field of GI stem cell biology, and the potential for tis...
Engineering Translational Models of Lung Homeostasis and Disease
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, m...
Imagined Homelands
A ground-breaking study of nineteenth-century British colonial poetry. Imagined Homelands chronicles the emerging cultures of nineteenth-century British settler colonialism, focusing on poetry as a genre especially equipped to reflect colonial experience. Jason Rudy argues that the poetry of Victorian-era Australia, New Zealand, South Africa, and Canada—often disparaged as derivative and uncouth—should instead be seen as vitally engaged in the social and political work of settlement. The book illuminates cultural pressures that accompanied the unprecedented growth of British emigration across the nineteenth century. It also explores the role of poetry as a mediator between familiar Briti...
Life, Death, and Eternity
Although uncertainty is an inherent part of life, it is universally agreed that death, as the end of an individual’s current known life, is inevitable. Yet extensive research and careful analysis of scientific literature seems to show that our existence may continue beyond what we currently understand. It is possible that we will transition through different stages, adapting to new environments and circumstances. Therefore, the future holds the potential for exciting discoveries and a deeper understanding of what it means to be alive. In an academic presentation, consultant geriatrician Dr. Kawa Amin delves into the fascinating realm of immortality and the attempts throughout history to ov...
Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere
Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.
The Rise and Fall of Animal Experimentation
Every year, hundreds of millions of animals are used in the service of biomedical research, despite the risk of extreme cruelty to these animal subjects. The expansion of the pharmaceutical industry and university research funding rapidly normalized its practice. What exactly are these experiments supposed to achieve from the scientific point of view and how effective are they? Working scientists answer these questions by saying that their research is absolutely necessary if we are to develop new therapies for human diseases. But is this really the case? Written by a scientist with over 40 years of laboratory experience, The Rise and Fall of Animal Experimentation critically examines this as...
Intestinal Stem Cell Niche
Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication
