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The Formation of the Swiss Hospital System (1840–1960)
This book offers an analysis of the formation of contemporary hospital systems between the mid-19th century and the mid-20th century. Based on extensive archival material and a broad international literature review, it focuses on the case of the canton of Vaud, Switzerland, and uses a triple approach that discusses technological innovations, hospital management, and health policy. This research is a major contribution to the history of medicine which gives a unique overview of the formation of contemporary hospital systems.
The link between brain energy homeostasis and neuronal activity
The brain is an extremely energy consuming part of the body, which makes it dangerously vulnerable to metabolic stress. It’s no wonder then that abnormalities of brain energy metabolism are becoming the usual suspects and a hallmark of many neurodegenerative diseases. The socioeconomic burden of these alone begs for urgent measures to be taken for better understanding both fundamental and applied problems of neuroenergetics and neuroprotection. For instance, brain imaging reveals that the diseased brains of Alzheimer’s patients cannot efficiently utilize the vital brain fuel, glucose. The resulting energy deficit causes neuronal hyperactivity, seizures and cognitive impairments. Administ...
Organelle Proteomics
This is the first book to examine organelle proteomics in depth. It begins by introducing the different analytical strategies developed and successfully utilized to study organelle proteomes, and detailing the use of multidimensional liquid chromatography coupled to tandem mass spectrometry for peptide sample analysis. Detailed protocols are provided and a section is devoted to methods enabling a global estimate of the reliability of the protein list assigned to an organelle.
Pierre-Gilles de Gennes
Best known outside the scientific community for the Nobel Prize in Physics he won in 1991, Pierre-Gilles de Gennes was exceptional amongst scientists for the breadth and depth of his contributions in multiple fields of physics. He was also much ahead of his time in his desire to break down barriers between scientific disciplines and between fundamental and applied science. He was equally unusual in his willingness to explain the nature and purpose of his work to society at large and to young people in particular. Laurence Pl(r)vert''s fascinating work retraces the influences and experiences that moulded this complex, charismatic, charming and eclectic genius. It follows him from his unconven...
International Review of Neurobiology
International Review of Neurobiology
Methods in Protein Sequence Analysis
The Ninth International Conference on Methods in Protein Sequence Analysis was held for the first time in Asia from September 20 to September 24, 1992 in Otsu (a city near Kyoto), Japan. Approximately 400 delegates attended the meeting. Forty papers were presented orally and 147 poster presentations were discussed. Academic sessions were held from early in the morning until late in the evening. We are confident that the Conference was successful in providing up-to-date information about methods in protein sequence analysis to all participants. Moreover, with the knowledge and understanding of the present standard of various methods of analysis that are being used and will be used, we were ab...
Between Neutrality and Solidarity: Swiss Good Offices in Afghanistan from 1979 to 1992
After 1979, Switzerland became increasingly involved in Soviet-occupied Afghanistan as a provider of humanitarian aid and good offices. It delivered aid to the region, hosted Soviet prisoners of war and eventually mediated between the Afghan regime and the mujahideen. What is puzzling about this development is that initially, following the Soviet invasion, both government and parliament refused to become diplomatically involved in Afghanistan on account of Swiss neutrality. The present study investigates how and why this changed between 1979 and 1992. While the practical impact of Switzerland’s good offices was modest, the crisis revealed that Switzerland continued to struggle to balance the competing imperatives of permanent neutrality and international solidarity in an increasingly multilateral world.
Cortical NO interneurons from embryogenesis to functions
Neuronal processing and physiology rely on a delicate interplay between glutamatergic excitatory neurons and GABAergic inhibitory interneurons in a spatially, temporally and cell-type specific manner. Understanding these processes is complicated further by the large diversity characterizing the cerebral cortex. Although recent advances have significantly improved our knowledge of its neuronal types, the identity and the roles of several subpopulations of GABAergic interneurons remain elusive. Presumably, because of their apparent paucity, their diversity, the highly labile nature of nitric oxide (NO) as well as its pleiotropic actions, the functional importance of NO-producing GABAergic interneurons is particularly enigmatic. This Research Topic will cover the different aspects of cortical NO interneurons, from their diversity, embryonic origins to their functions in the cortical circuit and physiology.
