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Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals
This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.
Advances in Clinical Chemistry
Advances in Clinical Chemistry, Volume 116, the latest release in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory
Metalloproteins and Motor Proteins
Metalloproteins and Motor Proteins, Volume 141 focuses on recent advances in studying metalloproteins and motor proteins, along with their roles in different pathologies and drug-resistance. Chapters include Transcriptomic Analysis Reveals Zinc-Mediated Virulence and Pathogenicity in Multidrug-Resistant Acinetobacter baumannii, The Mechanistic Insights into Different Aspects of Promiscuity in Metalloenzymes, Role of Metal ion in ion channel Mechanisms, A model of microtubule depolymerization by kinesin-8 motor proteins, Metalloproteins and metalloproteomics in health and disease, Decoding Genetic and Pathophysiological Mechanisms in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis...
Emerging Sample Treatments in Proteomics
Proteomics is a well-established area of Science; yet with a strong area in constant evolution, namely sample treatment. There few books that currently cover the field of emerging sample treatments in proteomics, this new volume will be the first to cover all emerging and existing studies. This unique book presents the latest advances in the field focusing on emerging trends linked to high-resolution mass spectrometry, technology addressed to treat samples faster and to attempts to simplify the proteome for the reader.
Metallomics
This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
ICP-MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions
ICP-MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions, Volume 97 discusses trace elements and how they play an important role in biological functions and metabolism in the human body. Chapters cover Biomedical analysis by ICP-MS: A focus on single cell, Advanced statistical tools and machine learning applied to trace element analysis associated with medical conditions, ICP-MS as a tool to understand trace element homeostasis in neurological disorders, High-precision isotopic analysis of essential mineral elements - possibilities for medical diagnosis and prognosis, Exploring ICP-MS as a versatile technique: From imaging to chemical speciation, and more. Discusses the latest diagnosis/pathologies using ICP-MS analysis Covers metals, isotopes and metalorganic species for medical conditions Includes ICP-MS-based techniques
ICP-MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions
ICP-MS and Trace Element Analysis as Tools for Better Understanding Medical Conditions, Volume 97 discusses trace elements and how they play an important role in biological functions and metabolism in the human body. Chapters cover Biomedical analysis by ICP-MS: A focus on single cell, Advanced statistical tools and machine learning applied to trace element analysis associated with medical conditions, ICP-MS as a tool to understand trace element homeostasis in neurological disorders, High-precision isotopic analysis of essential mineral elements – possibilities for medical diagnosis and prognosis, Exploring ICP-MS as a versatile technique: From imaging to chemical speciation, and more. Discusses the latest diagnosis/pathologies using ICP-MS analysis Covers metals, isotopes and metalorganic species for medical conditions Includes ICP-MS-based techniques
Smartphone-Based Detection Devices
Smartphone usage has created a new means for detection, analysis, diagnosis and monitoring through the use of new apps and attachments. These breakthrough analytical methods offer ways to overcome the drawbacks of more conventional methods, such as the expensive instrumentation that is often needed, complex sample pre-treatment steps, or time-consuming procedures. Smartphone-Based Detection Devices: Emerging Trends in Analytical Techniques gathers these modern developments in smartphone analytical methods into one comprehensive source, covering recent advancements in analytical tools while paying special attention to the most accurate, highly efficient approaches. Serving as a guide not only...
ENSAIOS NAS CIÊNCIAS AMBIENTAIS E AGRÁRIAS: Pesquisa e Desafios e Perspectivas – Vol. 4
A presente coletânea participam capítulos que abordam, de certa forma, uma variedade de tópicos relacionados às ciências ambientais e agrícolas, com ênfase na pesquisa e em todos os desafios e visões que a cercam. Durante sua elaboração, são apresentadas abordagens que se conectam às diversas áreas do conhecimento, através de propostas contemporâneas, destacando-se a contínua reflexão sobre a pesquisa e os desafios atuais, resultando em uma diversidade de vozes e perspectivas dos envolvidos.
