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Brain Stimulation
Deep brain stimulation has become an established treatment for advanced Parkinson’s disease. Its postoperative management is a delicate phase, dedicated to finding the optimal balance between stimulation and dopaminergic treatment. Postoperative management can be divided into an acute phase, aimed at the selection of the best stimulation contact, and a stabilization phase, aimed at the progressive adjustment of stimulation parameters and medications. A good knowledge of the electrophysiological anatomy of the target and surrounding structures, of the potential consequences of dopaminergic treatment modifications, and of the time course and interactions between stimulation and medication effects is mandatory for optimal outcome. This chapter focuses on the main strategies for the acute and chronic management of stimulation parameters and medication in the three main nuclei targeted in Parkinson’s disease, namely the subthalamic nucleus, the ventral intermediate thalamic nucleus, and the internal part of the globus pallidus.
Unmet Needs in Dystonia
This Research Topic contains proceedings of the final conference for COST Action BM1101 “Network of dystonia syndromes”. The topic highlights consolidated knowledge and unmet needs in a field that is evolving very fast. This publication is based upon work from COST Action BM1101, supported by COST (European Cooperation in Science and Technology).
Surgical Treatment of Parkinson’s Disease and Other Movement Disorders
In Surgical Treatment of Parkinson's Disease and Other Movement Disorders, a panel of highly experienced neurosurgeons, neurophysiologists, neuropsychologists, and neuroanatomists join forces to create an integrated, cutting-edge survey all of the methodologies necessary for successful surgical treatment.
Mechanisms and Emerging Therapies in Tremor Disorders
Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex up to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness and damping are all factors influencing features of tremor. This book discusses the pathophysiology of tremor including membrane mechanisms and rodent models, the advances in genetics and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment, and provides practical informations for the daily management. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced. Future challenges are also presented.
Deep Brain Stimulation
Deep Brain Stimulation: A New Frontier in Psychiatry provides an overview of current developments and the future possibilities of deep brain stimulation for patients with therapy-refractory psychiatric disorders. The side-by-side presentation of clinical applications and animal research provides a truly translational approach. Also included is a special chapter on the ethical issues involved in deep brain stimulation in psychiatry. Deep brain stimulation of selected brain areas has been shown to result in a substantial improvement of symptoms and quality of life in patients suffering from obsessive-compulsive disorder, major depressive disorder and drug addiction. Although it is still an experimental therapy and the number of psychiatric patients that are treated is low, its effectiveness and safety makes deep brain stimulation the most promising therapy for treating other serious and life-threatening psychiatric conditions.
»Dann zitter ich halt« – Leben trotz Parkinson
Parkinson ist nach Alzheimer die zweithäufigste neurodegenerative Erkrankung. Mehr als 350.000 Menschen im deutschsprachigen Raum sind an Parkinson erkrankt. Doch die Medizin hat gewaltige Fortschritte gemacht, eine Therapie ist heute viel besser möglich als noch vor wenigen Jahren. Frank Elstner, selbst betroffen, und der Neurologe Jens Volkmann geben Antworten auf die wichtigsten Fragen: Was sind die ersten Anzeichen von Parkinson? Wie ist der Krankheitsverlauf? Welche Therapien und Medikamente gibt es? Wie rede ich mit meinem Arzt? Wie kann man trotz Parkinson gut leben? Das Buch gibt Einblicke in den neusten Stand der Forschung, behält aber auch den Menschen mit Parkinson im Blick. Es wendet sich an Betroffene und ihre Angehörigen.
