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Tumor Budding in Colorectal Cancer
Tumour "budding", which is focused on in this book, is generally defined as an isolated single cancer cell or a cluster composed of a very small number of undifferentiated cancer cells in the stroma of the actively invasive front. The correlation of tumour budding with clinical outcome in colorectal cancer was first reported in the 1980s by Japanese surgeons. Since then, the clinical usefulness of this finding in colorectal cancer has been recognised in many countries. Its usefulness has been clarified not only as a prognostic factor and a potential parameter for a grading system, but also as an indicator for therapeutic decision making. Recently, more objective evaluation of tumour budding has been advocated, and the underlying mechanisms of tumour budding formation have been investigated at the molecular level. In this book, tumour budding in colorectal cancer is discussed from various perspectives. This book provides useful information for all investigators trying to deepen their understanding of colorectal cancer and develop evidence-based therapeutic strategies.
Early Detection of Cancer
Technological inventions allow us to identify molecular events that will effectively detect cancer earlier in biological specimens. This approach enables us to develop molecular biomarkers for detecting cancer early. It is believed that such a molecular marker approach enables the detection of the disease earlier.
Principles and Practice of Gastrointestinal Oncology
Thoroughly updated for its Second Edition, this text provides comprehensive, interdisciplinary coverage of gastrointestinal cancer, including molecular biology, diagnosis, medical, surgical, and radiation therapy, and palliative care. The initial section, Principles of Gastrointestinal Oncology, includes an expanded radiation oncology chapter, an extensively revised cancer genetics chapter, and a completely rewritten medical oncology chapter emphasizing new agents. Subsequent sections focus on esophageal, gastric, pancreatic, hepatocellular, biliary tree, and colorectal cancer. Coverage of each anatomic site includes epidemiology, screening, and prevention; molecular biology and genetics; pathology; anatomy and staging; and clinical management. The final section on uncommon cancers includes new chapters on neuroendocrine tumors and small bowel cancers. A companion Website provides instant access to the complete, fully searchable text.
Current Catalog
First multi-year cumulation covers six years: 1965-70.
In Defense of an Evolutionary Concept of Health
One of the most controversial contemporary debates on the concept of health is the clash between the views of naturalists and normativists. Naturalists argue that, although health can be valued or disvalued, the concept of health is itself objective and value-free. In contrast, normativists argue that health is a contextual and value-laden concept, and that there is no possibility of a value-free understanding of health. This debate has fueled many of the, often very acrimonious, disputations arising from the claims of health, disease and disability activists and charities and the public policy responses to them. In responding to this debate, Ananth both surveys the existing literature, with special focus on the work of Christopher Boorse, and argues that a naturalistic concept of health, drawing on evolutionary considerations associated with biological function, homeostasis, and species-design, is defensible without jettisoning norms in their entirety.
Genetics of Colorectal Cancer
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
DNA Methylation and Cancer Therapy
NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA ...
Molecular Pathology of Early Cancer
This book describes the principles and the application of the existing molecular methodology for the detection of early cancer. Discussion focuses on the molecular changes characterizing preneoplastic lesions; molecular targets for early detection; validation of molecular targets; and new diagnostic technology for early detection. The advantages of molecular detection over current methods are examined, as well as the importance of identifying and characterizing preneoplastic lesions. In addition to the uses of highly specific molecular probes to detect early cancer, this book demonstrates the many ways in which molecular markers serve oncology. While meeting pressing needs in the practice of medicine, molecular detection of early cancer scientifically necessitates a confrontation with the biology of cancer, such as the genetic determinants of progression, regression, dormancy, and invasion. This work not only discusses the diagnostic value of these molecular methods but views their practical benefits against a background of conventional morphology.
Understanding Colon Cancer
"For the general reader a concise manual of facts, warnings, preventions, treatments, and forecasts."--Cover.
