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Business/IT Fusion
Business/IT Fusion - How to move beyond alignment and transform IT in your organization is a business book authored by Peter Hinssen. It discusses an approach to IT management that moves beyond the classic model of business/IT alignment: alignment focused on the collaboration between business and IT, Hinssen suggests that the future evolution in IT lies in the convergence of the two parties: integrating IT into the business rather than treating it as asupplier. The work is presented as a guidebook to "IT 2.0"
Language Mapping
The Handbook of Language Mapping aims to explore the core methodological and theoretical approaches of linguistic cartography. In both empirical and theoretical linguistics, the spatial variation of language is of increasing interest and the visualization of language in space is therefore also of growing significance. It is the precondition for correct data interpretation. But how does it work? What has to be considered when drawing a map? And how has the problem been tackled so far? This book provides answers to such questions by taking a closer look at the theoretical issues surrounding cartography and at the concrete practice of mapping. The fundamental issues raised are addressed particu...
Toxoplasma Gondii Host Interactions: A Story of Immune Attack and Parasite Counterattack
Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasiteâ...
Analysis of Protein Post-Translational Modifications by Mass Spectrometry
Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research
Bart Simpson's Guide to Life
Move over Emily Post--America's favorite bad boy, Bart Simpson, has written his very own self-help book and etiquette manual. Filled with unscientific charts, colorful diagrams, questionable facts, and many other unique features.
HAC
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Hepatic Stem Cells
This volume looks at the liver’s epithelial cells—hepatocytes and cholangiocytes—and their progenitors. This book is divided into five parts: isolation of progenitor cells; characterization of liver progenitors in vivo; generation of hepatocytes, cholangiocytes, and their progenitors; reconstitution of liver tissue structures; and liver injury models. The chapters in this book cover topics such as expansion of bipotential liver stem/progenitor cells (LPCs) from fetal and neonatal liver; identifying progenitor cells involved in liver regeneration in vivo; methods for generating hepatocytes and cholangiocytes from multiple cellular sources; 3D tissue structures ex vivo; and resolving hep...
Metastatic Progression and Tumour Heterogeneity
Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.
