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Innovative Strategies and New Insights for the Treatment of Stage III Non-Small Cell Lung Cancer
Stage III NSCLC comprises a heterogeneous group of patients. It includes both resectable disease, for which the standard of care is surgery plus (neo) adjuvant chemotherapy/immunotherapy, and unresectable disease, for which the standard of care is concurrent chemoradiotherapy (CCRT) followed by one year of adjuvant durvalumab. Survival in stage III NSCLC is still poor, despite all the progress made in recent years, with the advent of immunotherapy. Many questions and unmet clinical needs are still to be addressed in both resectable and unresectable disease, in order to further improve patients' survival and limit toxicities. It is unlikely that a “one fits all” model or simply adding new drugs, represent the best solutions. Predictive biomarkers are strongly needed and identifying the patients who benefit the most from a specific treatment would be key. Adaptive strategies to spare unnecessary treatment (e.g. adjuvant therapy for patients cured with surgery alone) or to timely escalate therapy might also be important. With this Research Topic, we aim to shed some light on the best treatment for patients with stage III NSCLC.
Advances in the use of EGFR TKIs in the Treatment of NSCLC
Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all cases. Over the last decade, there have been significant advances in the treatment of NSCLC, particularly with the use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). EGFR is a key driver of NSCLC, and EGFR TKIs have shown remarkable clinical activity in patients with EGFR-mutant NSCLC. Despite these advances, however, there are still many unanswered questions regarding the optimal use of EGFR TKIs in the treatment of NSCLC. To improve patient outcomes, further research into the use of EGFR TKIs in lung cancer therapy is vital. Our goal is to provide an overview of the latest advances in the use of EGFR TKIs in the treatment of NSCLC.
Global Public Relations
This innovative text provides a structured and practical framework for understanding the complexities of contemporary public relations throughout the world and highlights the different approaches professionals must consider when communicating in different PR contexts.
Atlas of Equine Ultrasonography
The only visual guide to equine ultrasonography based on digital ultrasound technology. Atlas of Equine Ultrasonography provides comprehensive coverage of both musculoskeletal and non-musculoskeletal areas of the horse. Ideal for practitioners in first opinion or referral practices, each chapter features normal images for anatomical reference followed by abnormal images covering a broad range of recognised pathologies. The book is divided into musculoskeletal, reproductive and internal medicine sections and includes positioning diagrams demonstrating how to capture optimal images. With contributions from experts around the world, this book is the go-to reference for equine clinical ultrasonography. Key features include: Pictorially based with a wealth of digital ultrasound images covering both musculoskeletal and non-musculoskeletal areas and their associated pathologies. Each chapter begins with a discussion of normal anatomy and demonstrates how to obtain and interpret the images presented. A video library of over 50 ultrasound examinations is available for streaming or download and viewing on-the-go. Access details are provided in the book.
Biostatistics
The ability to analyze and interpret enormous amounts of data has become a prerequisite for success in allied healthcare and the health sciences. Now in its 11th edition, Biostatistics: A Foundation for Analysis in the Health Sciences continues to offer in-depth guidance toward biostatistical concepts, techniques, and practical applications in the modern healthcare setting. Comprehensive in scope yet detailed in coverage, this text helps students understand—and appropriately use—probability distributions, sampling distributions, estimation, hypothesis testing, variance analysis, regression, correlation analysis, and other statistical tools fundamental to the science and practice of medic...
