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Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes
  • Language: en
  • Pages: 297

Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes

Proceedings of a NATO ASI held in Antalya, Turkey, August 31 - September 11, 1997

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis
  • Language: en
  • Pages: 276

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis

  • Type: Book
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  • Published: 2020-12-29
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  • Publisher: MDPI

Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics.

Brenner's Encyclopedia of Genetics
  • Language: en
  • Pages: 4360

Brenner's Encyclopedia of Genetics

The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike.Featuring relatively short entries on genetics topics written by experts in that ...

New Horizons in Predictive Toxicology
  • Language: en
  • Pages: 711

New Horizons in Predictive Toxicology

The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessmen...

Cell Mechanics
  • Language: en
  • Pages: 484

Cell Mechanics

  • Type: Book
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  • Published: 2010-01-27
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  • Publisher: CRC Press

Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior

DNA Repair and Mutagenesis
  • Language: en
  • Pages: 2587

DNA Repair and Mutagenesis

An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

Applications of Pharmacokinetic Principles in Drug Development
  • Language: en
  • Pages: 556

Applications of Pharmacokinetic Principles in Drug Development

This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become ...

100 Chemical Myths
  • Language: en
  • Pages: 411

100 Chemical Myths

  • Type: Book
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  • Published: 2014-09-26
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  • Publisher: Springer

100 Chemical Myths deals with popular yet largely untrue misconceptions and misunderstandings related to chemistry. It contains lucid and concise explanations cut through fallacies and urban legends that are universally relevant to a global audience. A wide range of chemical myths are explored in these areas; food, medicines, catastrophes, chemicals, and environmental problems. Connections to popular culture, literature, movies, and cultural history hold the reader’s interest whilst key concepts are beautifully annotated with illustrations to facilitate the understanding of unfamiliar material. Chemical Myths Demystified is pitched to individuals without a formal chemistry background to fledgling undergraduate chemists to seasoned researchers and beyond.

Microbial Genetics
  • Language: en
  • Pages: 627

Microbial Genetics

  • Type: Book
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  • Published: 2024-06-10
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  • Publisher: CRC Press

This comprehensive book explores both the fundamental and practical aspects of microbial genetics, shedding light on viroids, viruses, phytoplasma, bacteria, fungi, and protozoa. Unveiling a fresh perspective, the book tackles traditional taxonomical debates by embracing DNA-based taxonomy, offering a novel approach to understanding phylogeny within this microbe realm. Furthermore, it delves into the exciting realm of metagenomics, revolutionizing the identification and classification of unculturable microorganisms. Written by leading experts, this essential reading material caters to students and researchers in Microbiology, Genetics, and Biotechnology.

Mining and Energy Law
  • Language: en
  • Pages: 415

Mining and Energy Law

  • Categories: Law

Mining and Energy Law is a thorough examination of the contemporary mining and energy sectors in Australia. It explores the law governing the current mix of sources utilised in the Australian energy sector, from petroleum and natural gas to renewable energy sources including wind and solar power.