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Case Reports in Neuro-Oncology and Neurosurgical Oncology : 2022
  • Language: en
  • Pages: 240

Case Reports in Neuro-Oncology and Neurosurgical Oncology : 2022

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Pharmacotherapy Principles and Practice, Third Edition
  • Language: en
  • Pages: 1969

Pharmacotherapy Principles and Practice, Third Edition

Learn the essential principles of pharmacotherapy and how they apply to today’s healthcare Pharmacotherapy Principles & Practice, Third Edition uses a solid evidence-based approach to teach you how to design, implement, monitor, and evaluate medication therapy. This trusted text provides everything you need to gain an in-depth understanding of the principles essential optimal pharmacotherapy of disease. In order to be as clinically relevant as possible, the disease states and treatments discussed focus on disorders most often seen in clinical practice. Chapters were written or reviewed by pharmacists, nurse practitioners, physician assistants, and physicians who are authorities in their fields. The book opens with an introductory chapter followed by chapters on pediatrics, geriatrics, and palliative care. The remainder of the text consists of ninety-eight disease-based chapters that review etiology, epidemiology, pathophysiology, and clinical presentation, followed by therapeutic recommendations for drug selection, dosing, and patient monitoring.

Gene Quantification
  • Language: en
  • Pages: 379

Gene Quantification

Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precurso...

The Burning Saints
  • Language: en
  • Pages: 266

The Burning Saints

  • Type: Book
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  • Published: 2014-10-14
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  • Publisher: Routledge

The Anastenaria are Orthodox Christians in Northern Greece who observe a unique annual ritual cycle focused on two festivals, dedicated to Saint Constantine and Saint Helen. The festivals involve processions, music, dancing, animal sacrifices, and culminate in an electrifying fire-walking ritual. Carrying the sacred icons of the saints, participants dance over hot coals as the saint moves them. 'The Burning Saints' presents an analysis of these rituals and the psychology behind them. Based on long-term fieldwork, 'The Burning Saints' traces the historical development and sociocultural context of the Greek fire-walking rituals. As a cognitive ethnography, the book aims to identify the social, psychological and neurobiological factors which may be involved and to explore the role of emotional and physiological arousal in the performance of such ritual. A study of participation, experience and meaning, 'The Burning Saints' presents a highly original analysis of how mental processes can shape social and religious behaviour.

Oncology Clinical Trials
  • Language: en
  • Pages: 396

Oncology Clinical Trials

Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the marketplace, and expand the horizon of contemporary thinking about cancer biology. A poorly done trial does little to advance the field or guide clinical practice, consumes precious clinical and financial resources and challenges the validity of the ethical contract between investigators and the volunteers who willingly give their time and effort to benef...

Clinical and Forensic Applications of Capillary Electrophoresis
  • Language: en
  • Pages: 449

Clinical and Forensic Applications of Capillary Electrophoresis

Because capillary electrophoresis (CE) is driving the automation of manual and semi-manual techniques, conserves precious samples, and minimizes the use of hazardous organic chemicals, it constitutes a powerful new methodology for the clinical laboratory. In Clinical and Forensic Applications of Capillary Electrophoresis, John R. Petersen and Amin A. Mohammad, along with a panel of leading basic and clinical investigators, review those CE methods that are now replacing many routine serum and blood tests in clinical and forensic laboratories. Major areas reviewed include the coating of columns; the analysis of serum, urine, and CSF proteins and paraproteins; abnormal hemoglobins and hemoglobi...

Journal of the National Cancer Institute
  • Language: en
  • Pages: 360

Journal of the National Cancer Institute

  • Type: Book
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  • Published: 1995-07
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  • Publisher: Unknown

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Insights into the Pharmaceutical and Clinical Applications of Nanoparticles in Cancer Therapy
  • Language: en
  • Pages: 350

Insights into the Pharmaceutical and Clinical Applications of Nanoparticles in Cancer Therapy

Healthcare has long been on a quest for a ‘magic bullet’ to cure the dreaded disease cancer. As this book shows, nanoparticles perfectly fit the bill with their promising characteristics. Meticulously engineered nanostructures, with a useful drug or molecule, target a specific cancer in unique ways. However, as with many targeted systems, the effectiveness of the system needs to be weighed against the adverse effects. The toxicity of nanoparticles has been a worldwide concern, and evidence-based medicine analyses nanostructures for proof of safety and their efficacy in killing cancer cells. This book gives a fresh perspective on a wealth of diverse nanotechnological advances for various cancers.

Human Subjects Research Regulation
  • Language: en
  • Pages: 393

Human Subjects Research Regulation

  • Categories: Law
  • Type: Book
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  • Published: 2014-07-11
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  • Publisher: MIT Press

The current framework for the regulation of human subjects research emerged largely in reaction to the horrors of Nazi human experiment, revealed at the Nuremburg trials, and the Tuskegee syphilis study, conducted by US government researchers from 1932 to 1972. This framework combining elements of paternalism with efforts to preserve individual autonomy, has remained fundamentally unchanged for decades Yet, as this book documents, it has significant flaws-including its potential to burden important research, overprotect some subjects and inadequately protect others, generate inconsistent results, and lag behind developments in how research is conducted. Invigorated by the US government's fir...

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
  • Language: en
  • Pages: 828

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new mate...