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This book discusses typical skin diseases from an immunological point of view, introducing the latest immunological techniques and practices. It begins with a brief overview of the human immune system, including the basic concepts and principles as well as the general symbols used in immunology. Part Two describes the human skin as an integral part of the immune system, explaining the immunological roles of major cellular and molecular composites in the skin. Part Three illustrates typical skin diseases that have immunological involvement (immunodermatological conditions). It describes 40 skin diseases, focusing on immunological causes, pathogenesis, pattern of reaction and treatment choices...
Cuproptosis is a new type of cell death induced by copper that differs from other types of programmed cell death. Copper ions were discovered to bind to lipoacyl proteins during the tricarboxylic acid (TCA) cycle, resulting in abnormal lipoacyl protein oligomerization. Moreover, copper ions can also reduce the level of iron-sulfur cluster proteins, thereby causing the toxic stress response in proteins and ultimately leading to cell death. So far, cuproptosis‘s role in tumors, as well as the underlying mechanisms, are still unclear and require further investigation. Recent research suggests that inducing programmed death of abnormal cells could be one of the future methods for disease treatment and prevention. It can slow the progression of the disease and, eventually, cure it by causing tumor cell cuproptosis. Currently, the drug delivery system has received a lot of attention. It is also a novel idea to treat tumors by developing a drug delivery system to induce abnormal cell cuproptosis, which will effectively reduce treatment complications and improve patients’ life quality.
This book contains all refereed papers accepted during the 14th International Conference on Complex Systems Design & Management CSD&M 2023 that took place in Beijing, People’s Republic of China by the end October 2023. Mastering complex systems requires an integrated understanding of industrial practices as well as sophisticated theoretical techniques and tools. This explains the creation of an annual go-between European and Asian forum dedicated to academic researchers and industrial actors working on complex industrial systems architecting, modeling and engineering. These proceedings cover the most recent trends in the emerging field of complex systems, both from an academic and professi...
This book constitutes the refereed proceedings of the 21st International Workshop, IWDW 2022, held in Guilin, China, during November 18-19, 2022. The 14 full papers included in this book were carefully reviewed and selected from 30 submissions. They were organized in topical sections as follows: Steganology, Forensics and Security Analysis, Watermarking.
This volume set constitutes the refereed proceedings of the 16th International Conference on Knowledge Science, Engineering and Management, KSEM 2023, which was held in Guangzhou, China, during August 16–18, 2023. The 114 full papers and 30 short papers included in this book were carefully reviewed and selected from 395 submissions. They were organized in topical sections as follows: knowledge science with learning and AI; knowledge engineering research and applications; knowledge management systems; and emerging technologies for knowledge science, engineering and management.
Zadeh's fuzzy set theory incorporates the impreciseness of data and evaluations, by imputting the degrees by which each object belongs to a set. Its success fostered theories that codify the subjectivity, uncertainty, imprecision, or roughness of the evaluations. Their rationale is to produce new flexible methodologies in order to model a variety of concrete decision problems more realistically. This Special Issue garners contributions addressing novel tools, techniques and methodologies for decision making (inclusive of both individual and group, single- or multi-criteria decision making) in the context of these theories. It contains 38 research articles that contribute to a variety of setups that combine fuzziness, hesitancy, roughness, covering sets, and linguistic approaches. Their ranges vary from fundamental or technical to applied approaches.