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Cancer Disparities
There has been remarkable progress in understanding, preventing, detecting, diagnosing, and treating cancer, resulting in a reduction of cancer incidence and mortality in the United States. Despite this, the cancer burden varies considerably by race/ethnicity and socioeconomic status. Cancer incidence rates vary markedly between racial/ethnic groups, but even more startling are the differences in outcome across groups. Cancer Disparities: Causes and Evidence-Based Solutions helps readers understand the scope and causes of this inequity by providing a detailed analysis of the many factors that result in cancer disparities across the cancer continuum, including the role of race/ethnicity, soci...
Greenfield's Surgery
The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images. This edition has new chapters on quality assessment, surgical education, and surgical processes in the hospital. Coverage of surgical subspecialty areas is more sharply focuse...
Publisher and Bookseller
Vols. for 1871-76, 1913-14 include an extra number, The Christmas bookseller, separately paged and not included in the consecutive numbering of the regular series.
Breast Cancer Metastasis and Drug Resistance
This volume comprehensively covers recent prrogress in breast cancer research. In an effort to successfully treat breast cancer, it is imperative to a) fully understand the disease with all its heterogeneity, b) understand the factors that influence the metastasis of breast cancer to distant organs making it lethal and c) understand the underlying processes that lead to the phenomenon of drug-resistance making the disease particularly incurable. The book explores all of these issues, including the phenomenon of epithelial-mesenchymal-transition, cancer stem cells as well as microRNAs in an attempt to better understand the disease in connection to its heterogeneity/metastasis/drug-resistance as well as to propose novel signaling pathways for therapeutic intervention. The profiling of tumors to molecularly classify breast cancers is also investigated so that customized targeted therapies can be developed.
Advances in Surgical Pathology: Prostate Cancer
A concise and updated review of prostate cancer pathologic diagnosis with emphasis on practical issues and recent developments in the field. Each chapter addresses the basic diagnostic features, differential diagnoses, pitfalls and ways to resolve the problem. Additionally, a brief introduction of prostate cancer screening, clinical management and treatment are summarized. Recent development of immunohistochemistry, molecular testing in the diagnosis, prognosis and treatment are also reviewed. Finally, current knowledge of molecular alteration of prostate cancer carcinogenesis and impact in diagnosis and treatment are discussed.
Puck
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Cell Cycle Deregulation in Cancer
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
