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Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson's Disease
We would like to acknowledge Prof Rejko Krueger, from University of Luxembourg, who acted as a coordinator contributing to the preparation of the proposal for this Research Topic as part of the GEoPD.
Neurogenetics in Neurology: From Molecular Neuroscience to Precision Medicine
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Integrative Omics in Parkinson's Disease
Integrative Omics in Parkinson's Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson's disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease. - Reviews evolution of omics technologies from the first identification of monogenic forms of Parkinson's disease - Outlines machine learning algorithm application to Parkinson's disease datasets - Reviews big datasets on gene-environment interactions, genomics, epigenetics, and transcriptomics - Identifies how the microbiome influences Parkinson's disease in mouse models and patients - Provides outlook for therapies with induced-pluripotent stem cell models
AI For Lawyers
Discover how artificial intelligence can improve how your organization practices law with this compelling resource from the creators of one of the world’s leading legal AI platforms. AI for Lawyers: How Artificial Intelligence is Adding Value, Amplifying Expertise, and Transforming Careers explains how artificial intelligence can be used to revolutionize your organization’s operations. Noah Waisberg and Dr. Alexander Hudek, a lawyer and a computer science Ph.D. who lead prominent legal AI business Kira Systems, have written an approachable and insightful book that will help you transform how your firm functions. AI for Lawyers explains how artificial intelligence can help your law firm: ...
Parkinson's Disease
Parkinson's disease (PD) is the second-most common neurodegenerative disease, currently affecting more than 10 million people worldwide. There is currently no identified treatment and only symptomatic relief can be offered. The disease has clinical and pathological definitions through its cardinal motor manifestations and substantia nigra neuronal loss associated with intraneuronal Lewy bodies, respectively. The molecular mechanisms that lead to neurodegeneration remain elusive. It is becoming increasingly apparent that genetic factors contribute to its complex pathogenesis, with 90 loci from genome-wide association studies and many monogenic causes unraveled in the past years. The knowledge acquired from their protein products revealed pathways of neurodegeneration that Mendelian and sporadic Parkinsonism may share. These pathways include synaptic, lysosomal, mitochondrial, and immune-mediated mechanisms of pathogenesis. This Special Issue, "Parkinson's Disease: Genetics and Pathogenesis", collected 12 high-quality papers, including 7 original research articles and 5 reviews, that seek to deepen the knowledge of multiple aspects related to Parkinsonism.
Countering Development
An ethnographic analysis of the visions of development and modernity underlying indigenous Colombian communities efforts to rebuild following a 1994 earthquake.
Re-orienting Western Feminisms
The agenda of contemporary western feminism focuses on equal participation in work and education, reproductive rights, and sexual freedom. But what does feminism mean to the women of rural India who work someone else's fields, young Thai girls in the sex industry in Bangkok, or Filipino maids working for wealthy women in Hong Kong? In this 1998 book, Chilla Bulbeck presents a bold challenge to the hegemony of white, western feminism in this incisive and wide-ranging exploration of the lived experiences of 'women of colour'. She examines debates on human rights, family relationships, sexuality, and notions of the individual and community to show how their meanings and significance in different parts of the world contest the issues which preoccupy contemporary Anglophone feminists. She then turns the focus back on Anglo culture to illustrate how the theories and politics of western feminism are viewed by non-western women.
